2w2m

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{{Seed}}
 
[[Image:2w2m.png|left|200px]]
[[Image:2w2m.png|left|200px]]
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==About this Structure==
==About this Structure==
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2W2M is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2M OCA].
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[[2w2m]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2M OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:19001363</ref><references group="xtra"/>
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<ref group="xtra">PMID:019001363</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Baysarowich, J.]]
[[Category: Baysarowich, J.]]
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[[Category: Talamo, F.]]
[[Category: Talamo, F.]]
[[Category: Cardiovascular disease]]
[[Category: Cardiovascular disease]]
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[[Category: Egf]]
 
[[Category: Familial hypercholesterolemia]]
[[Category: Familial hypercholesterolemia]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-receptor complex]]
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[[Category: Hydrolase/receptor]]
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[[Category: Ldlr]]
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[[Category: Lipid metabolism]]
[[Category: Lipid metabolism]]
[[Category: Lipid transport]]
[[Category: Lipid transport]]
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[[Category: Low-density lipoprotein receptor]]
 
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[[Category: Pcsk9]]
 
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[[Category: Proprotein convertase]]
 
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[[Category: Receptor]]
 
[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Steroid metabolism]]
[[Category: Steroid metabolism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:32:49 2010''
 

Revision as of 05:21, 24 August 2011

Template:STRUCTURE 2w2m

WT PCSK9-DELTAC BOUND TO WT EGF-A OF LDLR

Template:ABSTRACT PUBMED 19001363

About this Structure

2w2m is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Bottomley MJ, Cirillo A, Orsatti L, Ruggeri L, Fisher TS, Santoro JC, Cummings RT, Cubbon RM, Lo Surdo P, Calzetta A, Noto A, Baysarowich J, Mattu M, Talamo F, De Francesco R, Sparrow CP, Sitlani A, Carfi A. Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants. J Biol Chem. 2009 Jan 9;284(2):1313-23. Epub 2008 Nov 10. PMID:19001363 doi:10.1074/jbc.M808363200

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