1h2b
From Proteopedia
(New page: 200px<br /> <applet load="1h2b" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h2b, resolution 1.62Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1H2B is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]] with ZN, OCA and NAJ as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H2B OCA]]. | + | 1H2B is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]] with ZN, OCA and NAJ as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1]]. Structure known Active Site: OC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H2B OCA]]. |
==Reference== | ==Reference== | ||
The structure of an alcohol dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix., Guy JE, Isupov MN, Littlechild JA, J Mol Biol. 2003 Aug 29;331(5):1041-51. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12927540 12927540] | The structure of an alcohol dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix., Guy JE, Isupov MN, Littlechild JA, J Mol Biol. 2003 Aug 29;331(5):1041-51. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12927540 12927540] | ||
[[Category: Aeropyrum pernix]] | [[Category: Aeropyrum pernix]] | ||
| + | [[Category: Alcohol dehydrogenase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Guy, J.E.]] | [[Category: Guy, J.E.]] | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:23:56 2007'' |
Revision as of 10:19, 30 October 2007
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CRYSTAL STRUCTURE OF THE ALCOHOL DEHYDROGENASE FROM THE HYPERTHERMOPHILIC ARCHAEON AEROPYRUM PERNIX AT 1.65A RESOLUTION
Overview
The structure of the recombinant medium chain alcohol dehydrogenase (ADH), from the hyperthermophilic archaeon Aeropyrum pernix has been solved by, the multiple anomalous dispersion technique using the signal from the, naturally occurring zinc ions. The enzyme is a tetramer with 222 point, group symmetry. The ADH monomer is formed from a catalytic and a, cofactor-binding domain, with the overall fold similar to previously, solved ADH structures. The 1.62 A resolution A.pernix ADH structure is, that of the holo form, with the cofactor NADH bound into the cleft between, the two domains. The electron density found in the active site has been, interpreted to be octanoic acid, which has been shown to be an inhibitor, of the enzyme. This inhibitor is positioned with its carbonyl oxygen atom, ... [(full description)]
About this Structure
1H2B is a [Single protein] structure of sequence from [Aeropyrum pernix] with ZN, OCA and NAJ as [ligands]. Active as [Alcohol dehydrogenase], with EC number [1.1.1.1]. Structure known Active Site: OC1. Full crystallographic information is available from [OCA].
Reference
The structure of an alcohol dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix., Guy JE, Isupov MN, Littlechild JA, J Mol Biol. 2003 Aug 29;331(5):1041-51. PMID:12927540
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