1h2t
From Proteopedia
(New page: 200px<br /> <applet load="1h2t" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h2t, resolution 2.10Å" /> '''STRUCTURE OF THE HU...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1H2T is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with GDP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H2T OCA]]. | + | 1H2T is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with GDP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: CAP. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H2T OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: rnp domain]] | [[Category: rnp domain]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:24:55 2007'' |
Revision as of 10:20, 30 October 2007
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STRUCTURE OF THE HUMAN NUCLEAR CAP-BINDING-COMPLEX (CBC) IN COMPLEX WITH A CAP ANALOGUE M7GPPPG
Overview
The heterodimeric nuclear cap-binding complex (CBC) binds to the 5' cap, structure of RNAs in the nucleus and plays a central role in their diverse, maturation steps. We describe the crystal structure at 2.1 A resolution of, human CBC bound to an m(7)GpppG cap analogue. Comparison with the, structure of uncomplexed CBC shows that cap binding induces co-operative, folding around the dinucleotide of some 50 residues from the N- and, C-terminal extensions to the central RNP domain of the small subunit, CBP20. The cap-bound conformation of CBP20 is stabilized by an intricate, network of interactions both to the ligand and within the subunit, as well, as new interactions of the CBP20 N-terminal tail with the large subunit, CBP80. Although the structure is very different from that of other ... [(full description)]
About this Structure
1H2T is a [Protein complex] structure of sequences from [Homo sapiens] with GDP as [ligand]. Structure known Active Site: CAP. Full crystallographic information is available from [OCA].
Reference
Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex., Mazza C, Segref A, Mattaj IW, Cusack S, EMBO J. 2002 Oct 15;21(20):5548-57. PMID:12374755
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