1oj6
From Proteopedia
(New page: 200px<br /> <applet load="1oj6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oj6, resolution 1.95Å" /> '''HUMAN BRAIN NEUROGL...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1OJ6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]] with SO4 and HEM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OJ6 OCA]]. | + | 1OJ6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]] with SO4 and HEM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OJ6 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: oxygen transport]] | [[Category: oxygen transport]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:26:02 2007'' |
Revision as of 10:21, 30 October 2007
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HUMAN BRAIN NEUROGLOBIN THREE-DIMENSIONAL STRUCTURE
Overview
Neuroglobin, mainly expressed in vertebrate brain and retina, is a, recently identified member of the globin superfamily. Augmenting O(2), supply, neuroglobin promotes survival of neurons upon hypoxic injury, potentially limiting brain damage. In the absence of exogenous ligands, neuroglobin displays a hexacoordinated heme. O(2) and CO bind to the heme, iron, displacing the endogenous HisE7 heme distal ligand. Hexacoordinated, human neuroglobin displays a classical globin fold adapted to host the, reversible bis-histidyl heme complex and an elongated protein matrix, cavity, held to facilitate O(2) diffusion to the heme. The neuroglobin, structure suggests that the classical globin fold is endowed with striking, adaptability, indicating that hemoglobin and myoglobin are just two, examples ... [(full description)]
About this Structure
1OJ6 is a [Single protein] structure of sequence from [[1]] with SO4 and HEM as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity., Pesce A, Dewilde S, Nardini M, Moens L, Ascenzi P, Hankeln T, Burmester T, Bolognesi M, Structure. 2003 Sep;11(9):1087-95. PMID:12962627
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