1ad3
From Proteopedia
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| - | [[Image:1ad3.gif|left|200px]]<br /><applet load="1ad3" size=" | + | [[Image:1ad3.gif|left|200px]]<br /><applet load="1ad3" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ad3, resolution 2.6Å" /> | caption="1ad3, resolution 2.6Å" /> | ||
'''CLASS 3 ALDEHYDE DEHYDROGENASE COMPLEX WITH NICOTINAMIDE-ADENINE-DINUCLEOTIDE'''<br /> | '''CLASS 3 ALDEHYDE DEHYDROGENASE COMPLEX WITH NICOTINAMIDE-ADENINE-DINUCLEOTIDE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AD3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with NAD as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(NAD(P)(+)) Aldehyde dehydrogenase (NAD(P)(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.5 1.2.1.5] Known structural/functional Sites: <scene name='pdbsite=CTA:Catalytic CYS'>CTA</scene> and <scene name='pdbsite=CTB:Catalytic CYS'>CTB</scene>. Full crystallographic information is available from [http:// | + | 1AD3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=NAD:'>NAD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(NAD(P)(+)) Aldehyde dehydrogenase (NAD(P)(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.5 1.2.1.5] Known structural/functional Sites: <scene name='pdbsite=CTA:Catalytic+CYS'>CTA</scene> and <scene name='pdbsite=CTB:Catalytic+CYS'>CTB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AD3 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:29:48 2008'' |
Revision as of 07:29, 3 February 2008
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CLASS 3 ALDEHYDE DEHYDROGENASE COMPLEX WITH NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Overview
The first structure of an aldehyde dehydrogenase (ALDH) is described at, 2.6 A resolution. Each subunit of the dimeric enzyme contains an, NAD-binding domain, a catalytic domain and a bridging domain. At the, interface of these domains is a 15 A long funnel-shaped passage with a 6 x, 12 A opening leading to a putative catalytic pocket. A new mode of NAD, binding, which differs substantially from the classic beta-alpha-beta, binding mode associated with the 'Rossmann fold', is observed which we, term the beta-alpha,beta mode. Sequence comparisons of the class 3 ALDH, with other ALDHs indicate a similar polypeptide fold, novel NAD-binding, mode and catalytic site for this family. A mechanism for enzymatic, specificity and activity is postulated.
About this Structure
1AD3 is a Single protein structure of sequence from Rattus norvegicus with as ligand. Active as Aldehyde dehydrogenase (NAD(P)(+)), with EC number 1.2.1.5 Known structural/functional Sites: and . Full crystallographic information is available from OCA.
Reference
The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold., Liu ZJ, Sun YJ, Rose J, Chung YJ, Hsiao CD, Chang WR, Kuo I, Perozich J, Lindahl R, Hempel J, Wang BC, Nat Struct Biol. 1997 Apr;4(4):317-26. PMID:9095201
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