2ptk
From Proteopedia
(New page: 200px<br /> <applet load="2ptk" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ptk, resolution 2.35Å" /> '''CHICKEN SRC TYROSIN...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2PTK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.112 2.7.1.112]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2PTK OCA]]. | + | 2PTK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_2.7.10.1_and_2.7.10.2 Transferred entry: 2.7.10.1 and 2.7.10.2]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.112 2.7.1.112]]. Structure known Active Sites: S1 and S2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2PTK OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Transferred entry: 2.7.10.1 and 2.7.10.2]] | ||
[[Category: Wierenga, R.]] | [[Category: Wierenga, R.]] | ||
[[Category: Williams, J.C.]] | [[Category: Williams, J.C.]] | ||
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[[Category: tyrosine-protein kinase]] | [[Category: tyrosine-protein kinase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:26:36 2007'' |
Revision as of 10:21, 30 October 2007
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CHICKEN SRC TYROSINE KINASE
Overview
The Src protein tyrosine kinase plays a critical role in a variety of, signal transduction pathways. Strict regulation of its activity is, necessary for proper signalling. We present here the crystal structure of, chicken Src which is phosphorylated at Tyr527 and represents its least, active form. Our structure, similar to the recently reported human Hck and, Src structures, contains the SH3, SH2 and the kinase domains and the, C-terminal regulatory tail but not the N-terminal unique domain. The SH3, domain uses its hydrophobic surface to coordinate the SH2-kinase linker, such that residues Gln251 and Leu255 specifically interact with side, chains in the beta2-beta3 and the alphaC-beta4 loops of the N-terminal, lobe opposite of the kinase active site. This position of the SH3 domain, and ... [(full description)]
About this Structure
2PTK is a [Single protein] structure of sequence from [Gallus gallus]. Active as [Transferred entry: 2.7.10.1 and 2.7.10.2], with EC number [2.7.1.112]. Structure known Active Sites: S1 and S2. Full crystallographic information is available from [OCA].
Reference
The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions., Williams JC, Weijland A, Gonfloni S, Thompson A, Courtneidge SA, Superti-Furga G, Wierenga RK, J Mol Biol. 1997 Dec 19;274(5):757-75. PMID:9405157
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