1aq1
From Proteopedia
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| - | [[Image:1aq1.gif|left|200px]]<br /><applet load="1aq1" size=" | + | [[Image:1aq1.gif|left|200px]]<br /><applet load="1aq1" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1aq1, resolution 2.0Å" /> | caption="1aq1, resolution 2.0Å" /> | ||
'''HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE'''<br /> | '''HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AQ1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with STU as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37] Known structural/functional Site: <scene name='pdbsite=STB:Staurosporine Binding Site'>STB</scene>. Full crystallographic information is available from [http:// | + | 1AQ1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=STU:'>STU</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37] Known structural/functional Site: <scene name='pdbsite=STB:Staurosporine+Binding+Site'>STB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQ1 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: staurosporine]] | [[Category: staurosporine]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:31:16 2008'' |
Revision as of 07:31, 3 February 2008
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE
Overview
Staurosporine exhibits nanomolar IC50 values against a wide range of, protein kinases. The structure of a CDK2 staurosporine complex explains, the tight binding of this inhibitor, and suggests features to be exploited, in the design of specific inhibitors of CDKs.
About this Structure
1AQ1 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Transferred entry: 2.7.11.1, with EC number 2.7.1.37 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2., Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA, Nat Struct Biol. 1997 Oct;4(10):796-801. PMID:9334743
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