1bc5
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1bc5.gif|left|200px]]<br /><applet load="1bc5" size=" | + | [[Image:1bc5.gif|left|200px]]<br /><applet load="1bc5" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1bc5, resolution 2.2Å" /> | caption="1bc5, resolution 2.2Å" /> | ||
'''CHEMOTAXIS RECEPTOR RECOGNITION BY PROTEIN METHYLTRANSFERASE CHER'''<br /> | '''CHEMOTAXIS RECEPTOR RECOGNITION BY PROTEIN METHYLTRANSFERASE CHER'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1BC5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium] with CO, ACE and SAH as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein-glutamate_O-methyltransferase Protein-glutamate O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.80 2.1.1.80] Known structural/functional Site: <scene name='pdbsite=COB:Co Binding Site Is Formed By HIS 192 And HIS 114 Of Symm ...'>COB</scene>. Full crystallographic information is available from [http:// | + | 1BC5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium] with <scene name='pdbligand=CO:'>CO</scene>, <scene name='pdbligand=ACE:'>ACE</scene> and <scene name='pdbligand=SAH:'>SAH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein-glutamate_O-methyltransferase Protein-glutamate O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.80 2.1.1.80] Known structural/functional Site: <scene name='pdbsite=COB:Co+Binding+Site+Is+Formed+By+HIS+192+And+HIS+114+Of+Symm+...'>COB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BC5 OCA]. |
==Reference== | ==Reference== | ||
| Line 24: | Line 24: | ||
[[Category: peptide binding]] | [[Category: peptide binding]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:32:34 2008'' |
Revision as of 07:32, 3 February 2008
|
CHEMOTAXIS RECEPTOR RECOGNITION BY PROTEIN METHYLTRANSFERASE CHER
Overview
Signal transduction processes commonly involve reversible covalent, modifications of receptors. Bacterial chemotaxis receptors are reversibly, methylated at specific glutamate residues within coiled-coil regions of, their cytoplasmic domains. Methylation is catalyzed by an, S-adenosylmethionine-dependent protein methyltransferase, CheR, that binds, to a specific sequence at the C-termini of some chemotaxis receptors. From, this tethering point, CheR methylates neighboring receptor molecules. We, report the crystal structure, determined to 2.2 A resolution, of a complex, of the Salmonella typhimurium methyltransferase CheR bound to the, methylation reaction product, S-adenosylhomocysteine (AdoHcy), and the, C-terminal pentapeptide of the aspartate receptor, Tar. The structure, indicates the basis for the specificity of interaction between the, chemoreceptors and CheR and identifies a specific receptor binding motif, incorporated in the CheR methyltransferase domain.
About this Structure
1BC5 is a Single protein structure of sequence from Salmonella typhimurium with , and as ligands. Active as Protein-glutamate O-methyltransferase, with EC number 2.1.1.80 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Chemotaxis receptor recognition by protein methyltransferase CheR., Djordjevic S, Stock AM, Nat Struct Biol. 1998 Jun;5(6):446-50. PMID:9628482
Page seeded by OCA on Sun Feb 3 09:32:34 2008
