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1zac
From Proteopedia
(New page: 200px<br /> <applet load="1zac" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zac" /> '''N-DOMAIN OF TROPONIN C FROM CHICKEN SKELETA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1ZAC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ZAC OCA]]. | + | 1ZAC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]]. Structure known Active Sites: I and II. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ZAC OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: muscle protein]] | [[Category: muscle protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:27:10 2007'' |
Revision as of 10:22, 30 October 2007
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N-DOMAIN OF TROPONIN C FROM CHICKEN SKELETAL MUSCLE, NMR, MINIMIZED AVERAGE STRUCTURE
Overview
Contractile activity of skeletal muscle is triggered by a Ca2+-induced, "opening" of the regulatory N-domain of troponin C (apo-NTnC residues, 1-90). This structural transition has become a paradigm for large-scale, conformational changes that affect the interaction between proteins. The, regulatory domain is comprised of two basic structural elements: one, contributed by the N-, A-, and D-helices (NAD unit) and the other by the, B- and C-helices (BC unit). The Ca2+-induced opening is characterized by a, movement of the BC unit away from the NAD unit with a concomitant change, in conformation at two hinges (Glu41 and Val65) of the BC unit. To examine, the effect of low temperatures on this Ca2+-induced structural change and, the implications for contractile regulation, we have examined ... [(full description)]
About this Structure
1ZAC is a [Single protein] structure of sequence from [Gallus gallus]. Structure known Active Sites: I and II. Full crystallographic information is available from [OCA].
Reference
Low-temperature-induced structural changes in the Apo regulatory domain of skeletal muscle troponin C., Tsuda S, Miura A, Gagne SM, Spyracopoulos L, Sykes BD, Biochemistry. 1999 May 4;38(18):5693-700. PMID:10231519
Page seeded by OCA on Tue Oct 30 12:27:10 2007
