1be9
From Proteopedia
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| - | [[Image:1be9.gif|left|200px]]<br /><applet load="1be9" size=" | + | [[Image:1be9.gif|left|200px]]<br /><applet load="1be9" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1be9, resolution 1.82Å" /> | caption="1be9, resolution 1.82Å" /> | ||
'''THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 IN COMPLEX WITH A C-TERMINAL PEPTIDE DERIVED FROM CRIPT.'''<br /> | '''THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 IN COMPLEX WITH A C-TERMINAL PEPTIDE DERIVED FROM CRIPT.'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BE9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Known structural/functional Site: <scene name='pdbsite=PEP:Residues Involved In The Binding Of Four C-Terminal Resi ...'>PEP</scene>. Full crystallographic information is available from [http:// | + | 1BE9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Known structural/functional Site: <scene name='pdbsite=PEP:Residues+Involved+In+The+Binding+Of+Four+C-Terminal+Resi+...'>PEP</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BE9 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protein localization]] | [[Category: protein localization]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:32:45 2008'' |
Revision as of 07:32, 3 February 2008
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THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 IN COMPLEX WITH A C-TERMINAL PEPTIDE DERIVED FROM CRIPT.
Overview
Modular PDZ domains, found in many cell junction-associated proteins, mediate the clustering of membrane ion channels by binding to their, C-terminus. The X-ray crystallographic structures of the third PDZ domain, from the synaptic protein PSD-95 in complex with and in the absence of its, peptide ligand have been determined at 1.8 angstroms and 2.3 angstroms, resolution, respectively. The structures reveal that a four-residue, C-terminal stretch (X-Thr/Ser-X-Val-COO(-)) engages the PDZ domain through, antiparallel main chain interactions with a beta sheet of the domain., Recognition of the terminal carboxylate group of the peptide is conferred, by a cradle of main chain amides provided by a Gly-Leu-Gly-Phe loop as, well as by an arginine side chain. Specific side chain interactions and a, prominent hydrophobic pocket explain the selective recognition of the, C-terminal consensus sequence.
About this Structure
1BE9 is a Single protein structure of sequence from Rattus norvegicus. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ., Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R, Cell. 1996 Jun 28;85(7):1067-76. PMID:8674113
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