1bt7
From Proteopedia
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| - | [[Image:1bt7.gif|left|200px]]<br /><applet load="1bt7" size=" | + | [[Image:1bt7.gif|left|200px]]<br /><applet load="1bt7" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1bt7" /> | caption="1bt7" /> | ||
'''THE SOLUTION NMR STRUCTURE OF THE N-TERMINAL PROTEASE DOMAIN OF THE HEPATITIS C VIRUS (HCV) NS3-PROTEIN, FROM BK STRAIN, 20 STRUCTURES'''<br /> | '''THE SOLUTION NMR STRUCTURE OF THE N-TERMINAL PROTEASE DOMAIN OF THE HEPATITIS C VIRUS (HCV) NS3-PROTEIN, FROM BK STRAIN, 20 STRUCTURES'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BT7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gb_virus_c Gb virus c] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=CTS:Catalytic Site'>CTS</scene> and <scene name='pdbsite=ZNB:Zn Binding Site'>ZNB</scene>. Full crystallographic information is available from [http:// | + | 1BT7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gb_virus_c Gb virus c] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=CTS:Catalytic+Site'>CTS</scene> and <scene name='pdbsite=ZNB:Zn+Binding+Site'>ZNB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BT7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: viral non-structural protein]] | [[Category: viral non-structural protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:33:56 2008'' |
Revision as of 07:33, 3 February 2008
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THE SOLUTION NMR STRUCTURE OF THE N-TERMINAL PROTEASE DOMAIN OF THE HEPATITIS C VIRUS (HCV) NS3-PROTEIN, FROM BK STRAIN, 20 STRUCTURES
Overview
The solution structure of the hepatitis C virus (BK strain) NS3 protein, N-terminal domain (186 residues) has been solved by NMR spectroscopy. The, protein is a serine protease with a chymotrypsin-type fold, and is, involved in the maturation of the viral polyprotein. Despite the knowledge, that its activity is enhanced by the action of a viral protein cofactor, NS4A, the mechanism of activation is not yet clear. The analysis of the, folding in solution and the differences from the crystallographic, structures allow the formulation of a model in which, in addition to the, NS4A cofactor, the substrate plays an important role in the activation of, the catalytic mechanism. A unique structural feature is the presence of a, zinc-binding site exposed on the surface, subject to a slow conformational, exchange process.
About this Structure
1BT7 is a Single protein structure of sequence from Gb virus c with as ligand. Known structural/functional Sites: and . Full crystallographic information is available from OCA.
Reference
The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism., Barbato G, Cicero DO, Nardi MC, Steinkuhler C, Cortese R, De Francesco R, Bazzo R, J Mol Biol. 1999 Jun 4;289(2):371-84. PMID:10366511
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