1tmo
From Proteopedia
(New page: 200px<br /> <applet load="1tmo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tmo, resolution 2.5Å" /> '''TRIMETHYLAMINE N-OXI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1TMO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Shewanella_massilia Shewanella massilia]] with 2MD and 2MO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.6.9 1.6.6.9]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TMO OCA]]. | + | 1TMO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Shewanella_massilia Shewanella massilia]] with 2MD and 2MO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Trimethylamine-N-oxide_reductase Trimethylamine-N-oxide reductase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.6.9 1.6.6.9]]. Structure known Active Site: MOS. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TMO OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Shewanella massilia]] | [[Category: Shewanella massilia]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Trimethylamine-N-oxide reductase]] | ||
[[Category: Czjzek, M.]] | [[Category: Czjzek, M.]] | ||
[[Category: Giordano, G.]] | [[Category: Giordano, G.]] | ||
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[[Category: tmao reductase]] | [[Category: tmao reductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:27:43 2007'' |
Revision as of 10:23, 30 October 2007
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TRIMETHYLAMINE N-OXIDE REDUCTASE FROM SHEWANELLA MASSILIA
Overview
The periplasmic trimethylamine N-oxide (TMAO) reductase from the marine, bacteria Shewanella massilia is involved in a respiratory chain, having, trimethylamine N-oxide as terminal electron acceptor. This molybdoenzyme, belongs to the dimethyl sulfoxide (DMSO) reductase family, but has a, different substrate specificity than its homologous enzyme. While the DMSO, reductases reduce a broad spectra of organic S-oxide and N-oxide, compounds, TMAO reductase from Shewanella massilia reduces only TMAO as, the natural compound. The crystal structure was solved by molecular, replacement with the coordinates of the DMSO reductase from Rhodobacter, sphaeroides. The overall fold of the protein structure is essentially the, same as the DMSO reductase structures, organized into four domains. The, ... [(full description)]
About this Structure
1TMO is a [Single protein] structure of sequence from [Shewanella massilia] with 2MD and 2MO as [ligands]. Active as [Trimethylamine-N-oxide reductase], with EC number [1.6.6.9]. Structure known Active Site: MOS. Full crystallographic information is available from [OCA].
Reference
Crystal structure of oxidized trimethylamine N-oxide reductase from Shewanella massilia at 2.5 A resolution., Czjzek M, Dos Santos JP, Pommier J, Giordano G, Mejean V, Haser R, J Mol Biol. 1998 Nov 27;284(2):435-47. PMID:9813128
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