1cg8
From Proteopedia
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1CG8 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Dasyatis_akajei Dasyatis akajei] with <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=CMO:'>CMO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=HMA:O2 Binding Site'>HMA</scene> and <scene name='pdbsite=HMB:O2 Binding Site'>HMB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CG8 OCA]. | + | 1CG8 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Dasyatis_akajei Dasyatis akajei] with <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=CMO:'>CMO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=HMA:O2+Binding+Site'>HMA</scene> and <scene name='pdbsite=HMB:O2+Binding+Site'>HMB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CG8 OCA]. |
==Reference== | ==Reference== | ||
| Line 19: | Line 19: | ||
[[Category: oxygen transport]] | [[Category: oxygen transport]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:34:38 2008'' |
Revision as of 07:34, 3 February 2008
|
CO Form Hemoglobin from Dasyatis Akajei
Overview
The three-dimensional structures of the deoxy- and carbonmonoxyhaemoglobin, (Hb) from Dasyatis akajei, a stingray, have been determined at 1.6 and 1.9, A resolution, respectively. This is one of the most distantly related, vertebrate Hbs to human HbA. Both structures resemble the respective forms, of HbA, indicating that the alpha2beta2-type tetramer and the mode of the, quaternary structure change are common to Hbs of jawed vertebrates. Larger, deviations between D. akajei Hb and human HbA are observed in various, parts of the molecule, even in the E and F helices. Significant mutations, and/or conformational changes are also observed around the haems, in the, C-terminal region of the beta subunit, in the alpha1beta2 interface and in, the organic phosphate-binding site of HbA. Despite these structural, differences, the oxygen affinity, haem-haem interaction, Bohr effect and, organic phosphate effect of D. akajei Hb are all only moderately reduced., Compared with human HbA, the overall r.m.s. deviation of main-chain atoms, in the helical regions of bony fish Hbs is smaller than that of D. akajei, Hb.
About this Structure
1CG8 is a Protein complex structure of sequences from Dasyatis akajei with and as ligands. Known structural/functional Sites: and . Full crystallographic information is available from OCA.
Reference
Structures of the deoxy and CO forms of haemoglobin from Dasyatis akajei, a cartilaginous fish., Chong KT, Miyazaki G, Morimoto H, Oda Y, Park SY, Acta Crystallogr D Biol Crystallogr. 1999 Jul;55(Pt 7):1291-300. PMID:10393295
Page seeded by OCA on Sun Feb 3 09:34:38 2008
