1dth
From Proteopedia
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| - | [[Image:1dth.gif|left|200px]]<br /><applet load="1dth" size=" | + | [[Image:1dth.gif|left|200px]]<br /><applet load="1dth" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1dth, resolution 2.0Å" /> | caption="1dth, resolution 2.0Å" /> | ||
'''METALLOPROTEASE'''<br /> | '''METALLOPROTEASE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1DTH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox] with ZN, CA and BAT as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Atrolysin_C Atrolysin C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.42 3.4.24.42] Known structural/functional Sites: <scene name='pdbsite=CAA:Ca Ion Binding Site'>CAA</scene>, <scene name='pdbsite=CAB:Ca Ion Binding Site'>CAB</scene>, <scene name='pdbsite=ZNA:Zn Binding Site'>ZNA</scene> and <scene name='pdbsite=ZNB:Zn Binding Site'>ZNB</scene>. Full crystallographic information is available from [http:// | + | 1DTH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=BAT:'>BAT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Atrolysin_C Atrolysin C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.42 3.4.24.42] Known structural/functional Sites: <scene name='pdbsite=CAA:Ca+Ion+Binding+Site'>CAA</scene>, <scene name='pdbsite=CAB:Ca+Ion+Binding+Site'>CAB</scene>, <scene name='pdbsite=ZNA:Zn+Binding+Site'>ZNA</scene> and <scene name='pdbsite=ZNB:Zn+Binding+Site'>ZNB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DTH OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:35:41 2008'' |
Revision as of 07:35, 3 February 2008
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METALLOPROTEASE
Overview
Matrix metalloproteinase enzymes have been implicated in degenerative, processes like tumor cell invasion, metastasis, and arthritis. Specific, metalloproteinase inhibitors have been used to block tumor cell, proliferation. We have examined the interaction of batimastat (BB-94) with, a metalloproteinase [atrolysin C (Ht-d), EC 3.4.24.42] active site at, 2.0-angstroms resolution (R = 16.8%). The title structure exhibits an, unexpected binding geometry, with the thiophene ring deeply inserted into, the primary specificity site. This unprecedented binding geometry, dramatizes the significance of the cavernous primary specificity site, pointing the way for the design of a new generation of potential antitumor, drugs.
About this Structure
1DTH is a Single protein structure of sequence from Crotalus atrox with , and as ligands. Active as Atrolysin C, with EC number 3.4.24.42 Known structural/functional Sites: , , and . Full crystallographic information is available from OCA.
Reference
Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding., Botos I, Scapozza L, Zhang D, Liotta LA, Meyer EF, Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54. PMID:8610113
Page seeded by OCA on Sun Feb 3 09:35:41 2008
Categories: Atrolysin C | Crotalus atrox | Single protein | Botos, I. | Liotta, L.A. | Meyer, E.F. | Scapozza, L. | Zhang, D. | BAT | CA | ZN | Hydrolase | Metalloprotease | Venom | Zinc
