Plasminogen
From Proteopedia
(New page: {{STRUCTURE_1bml| PDB=1bml | SIZE=400| SCENE= |right|CAPTION=Plasmin catalytic domain complex with streptokinase, 1bml }} '''Plasmin''' (PLN) is a serine protease which is involved...) |
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{{STRUCTURE_1bml| PDB=1bml | SIZE=400| SCENE= |right|CAPTION=Plasmin catalytic domain complex with streptokinase, [[1bml]] }} | {{STRUCTURE_1bml| PDB=1bml | SIZE=400| SCENE= |right|CAPTION=Plasmin catalytic domain complex with streptokinase, [[1bml]] }} | ||
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== 3D Structures of plasminogen == | == 3D Structures of plasminogen == | ||
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| + | ===Plasminogen kringle 1=== | ||
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| + | [[1pkr]] - hPLG kringle 1 – human<BR /> | ||
| + | [[1cea]] - hPLG kringle 1 + e-aminocaprioic acid<BR /> | ||
| + | [[1hpj]], [[1hpk]] - hPLG kringle 1 + 6-aminohexanoic acid - NMR<BR /> | ||
| + | [[1ceb]] - hPLG kringle 1 + AMCHA | ||
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| + | ===Plasminogen kringle 2=== | ||
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| + | [[1b2i]] - hPLG kringle 2 (mutant) – NMR<BR /> | ||
| + | [[1i5k]] - hPLG kringle 2 (mutant) + M2 protein peptide<BR /> | ||
| + | [[2kj4]] – hPLG kringle 2 + M2 protein peptide – NMR<BR /> | ||
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| + | ===Plasminogen kringle 3=== | ||
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| + | [[2l0s]] - hPLG kringle 3 – NMR<BR /> | ||
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| + | ===Plasminogen kringle 4=== | ||
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| + | [[1pk4]], [[1pmk]], [[1pml]], [[1krn]] – hPLG kringle 4<BR /> | ||
| + | [[2pk4]] - hPLG kringle 4 + e-aminocaprioic acid | ||
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| + | ===Plasminogen kringle 5=== | ||
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| + | [[5hpg]] - hPLG kringle 5<BR /> | ||
| + | [[2knf]] - hPLG kringle 5 – NMR<BR /> | ||
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| + | ===Plasminogen catalytic domain=== | ||
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| + | [[1qrz]], [[1ddj]], [[1rjx]] – hPLG catalytic domain (mutant) | ||
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| + | ===Plasmin=== | ||
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| + | [[1bml]] – hPLN catalytic domain + streptokinase<BR /> | ||
| + | [[1bui]] – hPLN light chain + staphylokinase | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:39, 20 September 2011
Plasmin (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen plasminogen (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin. PLN domains are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues.
Contents |
3D Structures of plasminogen
Plasminogen kringle 1
1pkr - hPLG kringle 1 – human
1cea - hPLG kringle 1 + e-aminocaprioic acid
1hpj, 1hpk - hPLG kringle 1 + 6-aminohexanoic acid - NMR
1ceb - hPLG kringle 1 + AMCHA
Plasminogen kringle 2
1b2i - hPLG kringle 2 (mutant) – NMR
1i5k - hPLG kringle 2 (mutant) + M2 protein peptide
2kj4 – hPLG kringle 2 + M2 protein peptide – NMR
Plasminogen kringle 3
2l0s - hPLG kringle 3 – NMR
Plasminogen kringle 4
1pk4, 1pmk, 1pml, 1krn – hPLG kringle 4
2pk4 - hPLG kringle 4 + e-aminocaprioic acid
Plasminogen kringle 5
5hpg - hPLG kringle 5
2knf - hPLG kringle 5 – NMR
Plasminogen catalytic domain
1qrz, 1ddj, 1rjx – hPLG catalytic domain (mutant)
Plasmin
1bml – hPLN catalytic domain + streptokinase
1bui – hPLN light chain + staphylokinase
