1dyq
From Proteopedia
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| - | [[Image:1dyq.gif|left|200px]]<br /><applet load="1dyq" size=" | + | [[Image:1dyq.gif|left|200px]]<br /><applet load="1dyq" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1dyq, resolution 1.50Å" /> | caption="1dyq, resolution 1.50Å" /> | ||
'''STAPHYLOCOCCAL ENTEROTOXIN A MUTANT VACCINE'''<br /> | '''STAPHYLOCOCCAL ENTEROTOXIN A MUTANT VACCINE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1DYQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with ZN and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=ZN1:Zn Binding Site The Zn Ion Is Bound To Residues HIS A 18 ...'>ZN1</scene>. Full crystallographic information is available from [http:// | + | 1DYQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=ZN1:Zn+Binding+Site+The+Zn+Ion+Is+Bound+To+Residues+HIS+A+18+...'>ZN1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DYQ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: vaccine]] | [[Category: vaccine]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:36:03 2008'' |
Revision as of 07:36, 3 February 2008
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STAPHYLOCOCCAL ENTEROTOXIN A MUTANT VACCINE
Overview
Staphylococcal enterotoxins (SEs) are superantigenic protein toxins, responsible for a number of life-threatening diseases. The X-ray structure, of a staphylococcal enterotoxin A (SEA) triple-mutant (L48R, D70R, and, Y92A) vaccine reveals a cascade of structural rearrangements located in, three loop regions essential for binding the alpha subunit of major, histocompatibility complex class II (MHC-II) molecules. A comparison of, hypothetical model complexes between SEA and the SEA triple mutant with, MHC-II HLA-DR1 clearly shows disruption of key ionic and hydrophobic, interactions necessary for forming the complex. Extensive dislocation of, the disulfide loop in particular interferes with MHC-IIalpha binding. The, triple-mutant structure provides new insights into the loss of, superantigenicity and toxicity of an engineered superantigen and provides, a basis for further design of enterotoxin vaccines.
About this Structure
1DYQ is a Single protein structure of sequence from Staphylococcus aureus with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structural basis for abrogated binding between staphylococcal enterotoxin A superantigen vaccine and MHC-IIalpha., Krupka HI, Segelke BW, Ulrich RG, Ringhofer S, Knapp M, Rupp B, Protein Sci. 2002 Mar;11(3):642-51. PMID:11847286
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