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1e5d

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[[Image:1e5d.jpg|left|200px]]<br /><applet load="1e5d" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:1e5d.jpg|left|200px]]<br /><applet load="1e5d" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1e5d, resolution 2.50&Aring;" />
caption="1e5d, resolution 2.50&Aring;" />
'''RUBREDOXIN OXYGEN:OXIDOREDUCTASE (ROO) FROM ANAEROBE DESULFOVIBRIO GIGAS'''<br />
'''RUBREDOXIN OXYGEN:OXIDOREDUCTASE (ROO) FROM ANAEROBE DESULFOVIBRIO GIGAS'''<br />
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==About this Structure==
==About this Structure==
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1E5D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_gigas Desulfovibrio gigas] with FMN, FEO and OXY as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=FEA:Diiron Redox Catalytic Site For Direct Dioxygen To Water ...'>FEA</scene>, <scene name='pdbsite=FEB:Diiron Redox Catalytic Site For Direct Dioxygen To Water ...'>FEB</scene>, <scene name='pdbsite=FMA:Fmn Binding Site For Chain A'>FMA</scene> and <scene name='pdbsite=FMB:Fmn Binding Site For Chain B'>FMB</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E5D OCA].
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1E5D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_gigas Desulfovibrio gigas] with <scene name='pdbligand=FMN:'>FMN</scene>, <scene name='pdbligand=FEO:'>FEO</scene> and <scene name='pdbligand=OXY:'>OXY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=FEA:Diiron+Redox+Catalytic+Site+For+Direct+Dioxygen+To+Water+...'>FEA</scene>, <scene name='pdbsite=FEB:Diiron+Redox+Catalytic+Site+For+Direct+Dioxygen+To+Water+...'>FEB</scene>, <scene name='pdbsite=FMA:Fmn+Binding+Site+For+Chain+A'>FMA</scene> and <scene name='pdbsite=FMB:Fmn+Binding+Site+For+Chain+B'>FMB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5D OCA].
==Reference==
==Reference==
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[[Category: oxygenreductase]]
[[Category: oxygenreductase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 14:57:53 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:37:23 2008''

Revision as of 07:37, 3 February 2008

Image:1e5d.jpg

1e5d, resolution 2.50Å

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RUBREDOXIN OXYGEN:OXIDOREDUCTASE (ROO) FROM ANAEROBE DESULFOVIBRIO GIGAS

Overview

Desulfovibrio gigas is a strict anaerobe that contains a, well-characterized metabolic pathway that enables it to survive transient, contacts with oxygen. The terminal enzyme in this pathway, rubredoxin:oxygen oxidoreductase (ROO) reduces oxygen to water in a direct, and safe way. The 2.5 A resolution crystal structure of ROO shows that, each monomer of this homodimeric enzyme consists of a novel combination of, two domains, a flavodoxin-like domain and a Zn-beta-lactamase-like domain, that contains a di-iron center for dioxygen reduction. This is the first, structure of a member of a superfamily of enzymes widespread in strict and, facultative anaerobes, indicating its broad physiological significance.

About this Structure

1E5D is a Single protein structure of sequence from Desulfovibrio gigas with , and as ligands. Known structural/functional Sites: , , and . Full crystallographic information is available from OCA.

Reference

Structure of a dioxygen reduction enzyme from Desulfovibrio gigas., Frazao C, Silva G, Gomes CM, Matias P, Coelho R, Sieker L, Macedo S, Liu MY, Oliveira S, Teixeira M, Xavier AV, Rodrigues-Pousada C, Carrondo MA, Le Gall J, Nat Struct Biol. 2000 Nov;7(11):1041-5. PMID:11062560

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