1h3v
From Proteopedia
(New page: 200px<br /> <applet load="1h3v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h3v, resolution 3.1Å" /> '''CRYSTAL STRUCTURE OF...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1H3V is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H3V OCA]]. | + | 1H3V is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Structure known Active Site: 1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H3V OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: glycosylation]] | [[Category: glycosylation]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:29:02 2007'' |
Revision as of 10:24, 30 October 2007
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CRYSTAL STRUCTURE OF THE HUMAN IGG1 FC-FRAGMENT,GLYCOFORM (G2F)2,SG P212121
Overview
Antibodies may be viewed as adaptor molecules that provide a link between, humoral and cellular defence mechanisms. Thus, when antigen-specific IgG, antibodies form antigen/antibody immune complexes the effectively, aggregated IgG can activate a wide range of effector systems. Multiple, effector mechanisms result from cellular activation mediated through a, family of IgG-Fc receptors differentially expressed on leucocytes. It is, established that glycosylation of IgG-Fc is essential for recognition and, activation of these ligands. IgG antibodies predominate in human serum and, most therapeutic antibodies are of the IgG class.The IgG-Fc is a homodimer, of N-linked glycopeptide chains comprised of two immunoglobulin domains, (Cgamma2, Cgamma3) that dimerise via inter-heavy chain disulphide ... [(full description)]
About this Structure
1H3V is a [Single protein] structure of sequence from [Homo sapiens]. Structure known Active Site: 1. Full crystallographic information is available from [OCA].
Reference
Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity., Krapp S, Mimura Y, Jefferis R, Huber R, Sondermann P, J Mol Biol. 2003 Jan 31;325(5):979-89. PMID:12527303
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