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Antithrombin
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Michal Harel (Talk | contribs)
(New page: '''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. A-AT contains 4 occupied glycosylation sites and is found in blood palsma. B-AT contains only 3 occupied gly...)
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Revision as of 19:25, 26 September 2011
Antithrombin (AT) inactivates several enzymes of the coagulation cycle. A-AT contains 4 occupied glycosylation sites and is found in blood palsma. B-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interactin of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation.
3D structures of antithrombin
1att – AT-III – bovine
1e05 - ha-AT-III
1e04 – hb-AT-III
1dzg, 1oyh, 1t1f, 2beh, 2b4x, 2hij - hAT-III (mutant)
Antithrombin binary complexes
1azx, 1nq9, 3evj – hAT + heparin pentasaccharide
1e03 – ha-AT-III + heparin pentasaccharide
1dzh - hAT-III (mutant) + fluorescein
2gd4 - hAT-III (mutant) + coagulation factor X
1br8, 1jvq, 1lk6, 1r1l – hAT-III + peptide
Antithrombin ternary complexes
1sr5 - hAT-III + prothrombin + heparin heptasaccharide
1tb6 - hAT-III (mutant) + thrombin + heparin polysaccharide
2b5t - AT-III (mutant) + thrombin (mutant) + heparin polysaccharide
3kcg - hAT-III (mutant) + coagulation factor IXa + heparin pentasaccharide
