1gc1
From Proteopedia
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| - | [[Image:1gc1.gif|left|200px]]<br /><applet load="1gc1" size=" | + | [[Image:1gc1.gif|left|200px]]<br /><applet load="1gc1" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1gc1, resolution 2.5Å" /> | caption="1gc1, resolution 2.5Å" /> | ||
'''HIV-1 GP120 CORE COMPLEXED WITH CD4 AND A NEUTRALIZING HUMAN ANTIBODY'''<br /> | '''HIV-1 GP120 CORE COMPLEXED WITH CD4 AND A NEUTRALIZING HUMAN ANTIBODY'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GC1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=O:Water Hoh 1000 (Zero Occupancy) Marks The Location Of Ce ...'>O</scene>. Full crystallographic information is available from [http:// | + | 1GC1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=O:Water+Hoh+1000+(Zero+Occupancy)+Marks+The+Location+Of+Ce+...'>O</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GC1 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: t-cell surface glycoprotein cd4]] | [[Category: t-cell surface glycoprotein cd4]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:40:21 2008'' |
Revision as of 07:40, 3 February 2008
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HIV-1 GP120 CORE COMPLEXED WITH CD4 AND A NEUTRALIZING HUMAN ANTIBODY
Overview
The entry of human immunodeficiency virus (HIV) into cells requires the, sequential interaction of the viral exterior envelope glycoprotein, gp120, with the CD4 glycoprotein and a chemokine receptor on the cell surface., These interactions initiate a fusion of the viral and cellular membranes., Although gp120 can elicit virus-neutralizing antibodies, HIV eludes the, immune system. We have solved the X-ray crystal structure at 2.5 A, resolution of an HIV-1 gp120 core complexed with a two-domain fragment of, human CD4 and an antigen-binding fragment of a neutralizing antibody that, blocks chemokine-receptor binding. The structure reveals a cavity-laden, CD4-gp120 interface, a conserved binding site for the chemokine receptor, evidence for a conformational change upon CD4 binding, the nature of a, CD4-induced antibody epitope, and specific mechanisms for immune evasion., Our results provide a framework for understanding the complex biology of, HIV entry into cells and should guide efforts to intervene.
About this Structure
1GC1 is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus 1 with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody., Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA, Nature. 1998 Jun 18;393(6686):648-59. PMID:9641677
Page seeded by OCA on Sun Feb 3 09:40:21 2008
Categories: Homo sapiens | Human immunodeficiency virus 1 | Protein complex | Hendrickson, W.A. | Kwong, P.D. | Robinson, J. | Sodroski, J. | Sweet, R.W. | Wyatt, R. | NAG | Antigen-binding fragment of human immunoglobulin 17b | Complex (hiv envelope protein/cd4/fab) | Glycosylated protein | Hiv-1 exterior envelope gp120 | T-cell surface glycoprotein cd4
