1gio
From Proteopedia
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| - | [[Image:1gio.jpg|left|200px]]<br /><applet load="1gio" size=" | + | [[Image:1gio.jpg|left|200px]]<br /><applet load="1gio" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1gio" /> | caption="1gio" /> | ||
'''NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES'''<br /> | '''NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GIO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Known structural/functional Site: <scene name='pdbsite=RIB:Ribonucleolytic Active Site'>RIB</scene>. Full crystallographic information is available from [http:// | + | 1GIO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Known structural/functional Site: <scene name='pdbsite=RIB:Ribonucleolytic+Active+Site'>RIB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GIO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: hydrolase angiogenesis]] | [[Category: hydrolase angiogenesis]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:40:25 2008'' |
Revision as of 07:40, 3 February 2008
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NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES
Overview
The three-dimensional structure of bovine angiogenin has been determined, using two- and three-dimensional proton NMR spectroscopy. The solution, structure is very close to that recently determined by X-ray diffraction, analysis. This structure appears well defined, even if five loops and one, helix exhibit greater flexibility. Analysis of the active site geometry, confirms the position of the Glu-118 residue which obstructs the, pyrimidine binding site. There is no experimental evidence of an, unobstructed conformation of angiogenin in solution. In addition, it, appears that the Glu-118 and Ser-119 residues and the cell receptor, binding loop may play an important role in the differences of C-terminal, fragment organization and ribonucleolytic activity observed between, angiogenins and ribonuclease A.
About this Structure
1GIO is a Single protein structure of sequence from Bos taurus. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Solution structure of bovine angiogenin by 1H nuclear magnetic resonance spectroscopy., Lequin O, Albaret C, Bontems F, Spik G, Lallemand JY, Biochemistry. 1996 Jul 9;35(27):8870-80. PMID:8688423
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