This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1h30
From Proteopedia
(New page: 200px<br /> <applet load="1h30" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h30, resolution 2.2Å" /> '''C-TERMINAL LG DOMAIN...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1H30 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA and SO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H30 OCA]]. | + | 1H30 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA and SO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: CAA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H30 OCA]]. |
==Reference== | ==Reference== | ||
| Line 30: | Line 30: | ||
[[Category: vitamin k-dependent protein]] | [[Category: vitamin k-dependent protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:30:16 2007'' |
Revision as of 10:25, 30 October 2007
|
C-TERMINAL LG DOMAIN PAIR OF HUMAN GAS6
Overview
Receptor tyrosine kinases of the Axl family are activated by Gas6, the, product of growth arrest-specific gene 6. Gas6-Axl signaling is implicated, in cell survival, adhesion, and migration. The receptor-binding site of, Gas6 is located within a C-terminal pair of laminin G-like (LG) domains, that do not resemble any other receptor tyrosine kinase ligand. We report, the crystal structure at 2.2-A resolution of a Gas6 fragment spanning both, LG domains (Gas6-LG). The structure reveals a V-shaped arrangement of LG, domains strengthened by an interdomain calcium-binding site. LG2 of, Gas6-LG contains two unusual features: an alpha-helix cradled by one edge, of the LG beta-sandwich and a conspicuous patch of surface-exposed, hydrophobic residues. Mutagenesis of some residues in this patch ... [(full description)]
About this Structure
1H30 is a [Single protein] structure of sequence from [Homo sapiens] with CA and SO4 as [ligands]. Structure known Active Site: CAA. Full crystallographic information is available from [OCA].
Reference
Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domains., Sasaki T, Knyazev PG, Cheburkin Y, Gohring W, Tisi D, Ullrich A, Timpl R, Hohenester E, J Biol Chem. 2002 Nov 15;277(46):44164-70. Epub 2002 Sep 5. PMID:12218057
Page seeded by OCA on Tue Oct 30 12:30:16 2007
