1gp7
From Proteopedia
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| - | [[Image:1gp7.gif|left|200px]]<br /><applet load="1gp7" size=" | + | [[Image:1gp7.gif|left|200px]]<br /><applet load="1gp7" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1gp7, resolution 2.6Å" /> | caption="1gp7, resolution 2.6Å" /> | ||
'''ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH'''<br /> | '''ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GP7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] Known structural/functional Site: <scene name='pdbsite=CAA:Ca Binding Site For Chain C'>CAA</scene>. Full crystallographic information is available from [http:// | + | 1GP7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] Known structural/functional Site: <scene name='pdbsite=CAA:Ca+Binding+Site+For+Chain+C'>CAA</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GP7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: snake venom]] | [[Category: snake venom]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:41:33 2008'' |
Revision as of 07:41, 3 February 2008
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ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH
Overview
The crystal structure of an acidic phospholipase A(2) from Ophiophagus, hannah (king cobra) has been determined by molecular replacement at 2.6-A, resolution to a crystallographic R factor of 20.5% (R(free)=23.3%) with, reasonable stereochemistry. The venom enzyme contains an unusual, "pancreatic loop." The conformation of the loop is well defined and, different from those in pancreas PLA(2), showing its structural, variability. This analysis provides the first structure of a PLA(2)-type, cardiotoxin. The sites related to the cardiotoxic and myotoxic activities, are explored and the oligomer observed in the crystalline state is, described.
About this Structure
1GP7 is a Single protein structure of sequence from Ophiophagus hannah with as ligand. Active as Phospholipase A(2), with EC number 3.1.1.4 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of a cardiotoxic phospholipase A(2) from Ophiophagus hannah with the "pancreatic loop"., Zhang HL, Xu SJ, Wang QY, Song SY, Shu YY, Lin ZJ, J Struct Biol. 2002 Jun;138(3):207-15. PMID:12217659
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