1gpf
From Proteopedia
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| - | [[Image:1gpf.gif|left|200px]]<br /><applet load="1gpf" size=" | + | [[Image:1gpf.gif|left|200px]]<br /><applet load="1gpf" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1gpf, resolution 1.85Å" /> | caption="1gpf, resolution 1.85Å" /> | ||
'''CHITINASE B FROM SERRATIA MARCESCENS IN COMPLEX WITH INHIBITOR PSAMMAPLIN'''<br /> | '''CHITINASE B FROM SERRATIA MARCESCENS IN COMPLEX WITH INHIBITOR PSAMMAPLIN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GPF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] Known structural/functional Site: <scene name='pdbsite=AC1:So4 Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1GPF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] Known structural/functional Site: <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GPF OCA]. |
==Reference== | ==Reference== | ||
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[[Category: inhibitor psammaplin]] | [[Category: inhibitor psammaplin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:41:34 2008'' |
Revision as of 07:41, 3 February 2008
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CHITINASE B FROM SERRATIA MARCESCENS IN COMPLEX WITH INHIBITOR PSAMMAPLIN
Overview
Several brominated tyrosine derived compounds, psammaplins A (1), K (2), and L (3) as well as bisaprasin (4) were isolated from the Fijian marine, sponge Aplysinella rhax during a bioassay guided isolation protocol. Their, structures were determined using NMR and MS techniques. Psammaplin A was, found to moderately inhibit chitinase B from Serratia marcescens, the mode, of inhibition being non-competitive. Crystallographic studies suggest that, a disordered psammaplin A molecule is bound near the active site., Interestingly, psammaplin A was found to be a potent antifungal agent.
About this Structure
1GPF is a Single protein structure of sequence from Serratia marcescens with as ligand. Active as Chitinase, with EC number 3.2.1.14 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax., Tabudravu JN, Eijsink VG, Gooday GW, Jaspars M, Komander D, Legg M, Synstad B, van Aalten DM, Bioorg Med Chem. 2002 Apr;10(4):1123-8. PMID:11836123
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