1gu2
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1gu2.jpg|left|200px]]<br /><applet load="1gu2" size=" | + | [[Image:1gu2.jpg|left|200px]]<br /><applet load="1gu2" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1gu2, resolution 1.19Å" /> | caption="1gu2, resolution 1.19Å" /> | ||
'''CRYSTAL STRUCTURE OF OXIDIZED CYTOCHROME C" FROM METHYLOPHILUS METHYLOTROPHUS'''<br /> | '''CRYSTAL STRUCTURE OF OXIDIZED CYTOCHROME C" FROM METHYLOPHILUS METHYLOTROPHUS'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1GU2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus] with HEC as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=HEA:Hec Binding Site For Chain B'>HEA</scene>. Full crystallographic information is available from [http:// | + | 1GU2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus] with <scene name='pdbligand=HEC:'>HEC</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=HEA:Hec+Binding+Site+For+Chain+B'>HEA</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GU2 OCA]. |
==Reference== | ==Reference== | ||
| Line 22: | Line 22: | ||
[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:42:38 2008'' |
Revision as of 07:42, 3 February 2008
|
CRYSTAL STRUCTURE OF OXIDIZED CYTOCHROME C" FROM METHYLOPHILUS METHYLOTROPHUS
Overview
The crystal structures of the oxidized and reduced forms of cytochrome c", from Methylophilus methylotrophus were solved from X-ray synchrotron data, to atomic resolution. The overall fold of the molecule in the two redox, states is very similar and is comparable to that of the oxygen-binding, protein from the purple phototrophic bacterium Rhodobacter sphaeroides., However, significant modifications occur near the haem group, in, particular the detachment from axial binding of His95 observed upon, reduction as well as the adoption of different conformations of some, protonatable residues that form a possible proton path from the haem, pocket to the protein surface. These changes are associated with the, previously well characterized redox-Bohr behaviour of this protein., Furthermore they provide a model for one of the presently proposed, mechanisms of proton translocation in the much more complex protein, cytochrome c oxidase.
About this Structure
1GU2 is a Single protein structure of sequence from Methylophilus methylotrophus with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structural evidence for a proton transfer pathway coupled with haem reduction of cytochrome c" from Methylophilus methylotrophus., Enguita FJ, Pohl E, Turner DL, Santos H, Carrondo MA, J Biol Inorg Chem. 2006 Mar;11(2):189-96. Epub 2005 Dec 10. PMID:16341897
Page seeded by OCA on Sun Feb 3 09:42:38 2008
