1gv4
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1gv4.jpg|left|200px]]<br /><applet load="1gv4" size=" | + | [[Image:1gv4.jpg|left|200px]]<br /><applet load="1gv4" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1gv4, resolution 2.00Å" /> | caption="1gv4, resolution 2.00Å" /> | ||
'''MURINE APOPTOSIS-INDUCING FACTOR (AIF)'''<br /> | '''MURINE APOPTOSIS-INDUCING FACTOR (AIF)'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1GV4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with FAD as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Fad Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1GV4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=FAD:'>FAD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Fad+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA]. |
==Reference== | ==Reference== | ||
| Line 22: | Line 22: | ||
[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:42:58 2008'' |
Revision as of 07:42, 3 February 2008
|
MURINE APOPTOSIS-INDUCING FACTOR (AIF)
Overview
Mitochondria play a key role in apoptosis due to their capacity to release, potentially lethal proteins. One of these latent death factors is, cytochrome c, which can stimulate the proteolytic activation of caspase, zymogens. Another important protein is apoptosis-inducing factor (AIF), a, flavoprotein that can stimulate a caspase-independent cell-death pathway, required for early embryonic morphogenesis. Here, we report the crystal, structure of mouse AIF at 2.0 A. Its active site structure and redox, properties suggest that AIF functions as an electron transferase with a, mechanism similar to that of the bacterial ferredoxin reductases, its, closest evolutionary homologs. However, AIF structurally differs from, these proteins in some essential features, including a long insertion in a, C-terminal beta-hairpin loop, which may be related to its apoptogenic, functions.
About this Structure
1GV4 is a Single protein structure of sequence from Mus musculus with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The crystal structure of the mouse apoptosis-inducing factor AIF., Mate MJ, Ortiz-Lombardia M, Boitel B, Haouz A, Tello D, Susin SA, Penninger J, Kroemer G, Alzari PM, Nat Struct Biol. 2002 Jun;9(6):442-6. PMID:11967568
Page seeded by OCA on Sun Feb 3 09:42:58 2008
Categories: Mus musculus | Single protein | Alzari, P.M. | Mate, M.J. | FAD | Apoptosi | Fad | Flavoprotein | Nuclear protein | Oxidoreductase
