1gz6
From Proteopedia
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| - | [[Image:1gz6.gif|left|200px]]<br /><applet load="1gz6" size=" | + | [[Image:1gz6.gif|left|200px]]<br /><applet load="1gz6" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1gz6, resolution 2.38Å" /> | caption="1gz6, resolution 2.38Å" /> | ||
'''(3R)-HYDROXYACYL-COA DEHYDROGENASE FRAGMENT OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2'''<br /> | '''(3R)-HYDROXYACYL-COA DEHYDROGENASE FRAGMENT OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GZ6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with SO4 and NAI as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Estradiol_17-beta-dehydrogenase Estradiol 17-beta-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62] Known structural/functional Site: <scene name='pdbsite=AC1:Nai Binding Site For Chain C'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1GZ6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=NAI:'>NAI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Estradiol_17-beta-dehydrogenase Estradiol 17-beta-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62] Known structural/functional Site: <scene name='pdbsite=AC1:Nai+Binding+Site+For+Chain+C'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZ6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: steroid biosynthesis]] | [[Category: steroid biosynthesis]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:44:14 2008'' |
Revision as of 07:44, 3 February 2008
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(3R)-HYDROXYACYL-COA DEHYDROGENASE FRAGMENT OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2
Overview
The crystal structure of (3R)-hydroxyacyl-CoA dehydrogenase of rat, peroxisomal multifunctional enzyme type 2 (MFE-2) was solved at 2.38 A, resolution. The catalytic entity reveals an alpha/beta short chain alcohol, dehydrogenase/reductase (SDR) fold and the conformation of the bound, nicotinamide adenine dinucleotide (NAD(+)) found in other SDR enzymes. Of, great interest is the separate COOH-terminal domain, which is not seen in, other SDR structures. This domain completes the active site cavity of the, neighboring monomer and extends dimeric interactions. Peroxisomal diseases, that arise because of point mutations in the dehydrogenase-coding region, of the MFE-2 gene can be mapped to changes in amino acids involved in, NAD(+) binding and protein dimerization.
About this Structure
1GZ6 is a Single protein structure of sequence from Rattus norvegicus with and as ligands. Active as Estradiol 17-beta-dehydrogenase, with EC number 1.1.1.62 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution., Haapalainen AM, Koski MK, Qin YM, Hiltunen JK, Glumoff T, Structure. 2003 Jan;11(1):87-97. PMID:12517343
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