1dxy
From Proteopedia
(New page: 200px<br /> <applet load="1dxy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dxy, resolution 1.86Å" /> '''STRUCTURE OF D-2-HY...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1DXY is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]] with SO4, NAD and COI as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DXY OCA]]. | + | 1DXY is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]] with SO4, NAD and COI as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: CAT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DXY OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:31:36 2007'' |
Revision as of 10:26, 30 October 2007
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STRUCTURE OF D-2-HYDROXYISOCAPROATE DEHYDROGENASE
Overview
D-2-hydroxyisocaproate dehydrogenase (D-HicDH) from Lactobacillus casei is, a homodimer with 333 amino acids and a molecular mass of 37 kDa per, subunit. The enzyme belongs to the protein family of NAD+-dependent, D-2-hydroxycarboxylate dehydrogenases and within this family to the, subgroup of D-lactate dehydrogenases (D-LDHs). Compared with other D-LDHs, D-HicDH is characterized by a very low specificity regarding size and, chemical constitution of the accepted D-2-hydroxycarboxylates. Hexagonal, crystals of recombinant D-HicDH in the presence of NAD+ and, 2-oxoisocaproate (4-methyl-2-oxopentanoate) were grown with ammonium, sulphate as precipitating agent. The structure of these crystals was, solved by molecular replacement and refined to a final R-factor of 19.6%, for all measured ... [(full description)]
About this Structure
1DXY is a [Single protein] structure of sequence from [Lactobacillus casei] with SO4, NAD and COI as [ligands]. Structure known Active Site: CAT. Full crystallographic information is available from [OCA].
Reference
Crystal structure of a ternary complex of D-2-hydroxyisocaproate dehydrogenase from Lactobacillus casei, NAD+ and 2-oxoisocaproate at 1.9 A resolution., Dengler U, Niefind K, Kiess M, Schomburg D, J Mol Biol. 1997 Apr 4;267(3):640-60. PMID:9126843
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