Serine/threonine protein kinase
From Proteopedia
(New page: '''Serine/threonine protein kinase''' Chk1 (Chk1) phosphorylates cdc25A, cdc25B and cdc25C. Upon phosphorylation, cdc25 binds adaptor protein and the cell is prevented from entering mit...) |
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'''Serine/threonine protein kinase''' Chk1 (Chk1) phosphorylates cdc25A, cdc25B and cdc25C. Upon phosphorylation, cdc25 binds adaptor protein and the cell is prevented from entering mitosis. Chk2 phosphorylates cdc25C at Ser-216. | '''Serine/threonine protein kinase''' Chk1 (Chk1) phosphorylates cdc25A, cdc25B and cdc25C. Upon phosphorylation, cdc25 binds adaptor protein and the cell is prevented from entering mitosis. Chk2 phosphorylates cdc25C at Ser-216. | ||
Revision as of 19:09, 12 October 2011
Serine/threonine protein kinase Chk1 (Chk1) phosphorylates cdc25A, cdc25B and cdc25C. Upon phosphorylation, cdc25 binds adaptor protein and the cell is prevented from entering mitosis. Chk2 phosphorylates cdc25C at Ser-216.
3D structures of serine/threonine protein kinase
Chk1
1nvq, 1nvr – hChk1 kinase domain+ peptide + saurosporine – human
1nvs, 1zys - hChk1 kinase domain + peptide + inhibitor
2cgu, 2cgv, 2cgw, 2cgx, 2c3j, 2c3k, 2c3l, 2br1, 2brb, 2brg, 2brh, 2brm, 2brn, 2bro, 2ayp, 2gdo, 2ghg, 2hog, 2ywp, 2hxl, 2hxq, 2hy0, 2r0u, 2e9n, 2e9o, 2e9p, 2e9u, 2e9v, 2qhm, 2qhn, 3f9n, 2wmq, 2wmr, 2wms, 2wmt, 2mwu, 2mwv, 2mwx, 3jvr, 3jvs, 2xey, 2xf0, 2xez, 2x8d, 2x8e, 2x8i, 3ot3, 3ot8, 3pa3, 3pa4, 3pa5, 3nlb - hChk1 kinase domain + inhibitor
Chk2
1gxc – hChk2 phosphothreonine-binding domain + phosphopeptide
2cn5 – hChk2 kinase domain + ADP
2cn8 – hChk2 kinase domain + inhibitor
2w0j, 2w7x, 2wtc, 2wtd, 2xbj, 2xm8, 2xm9, 2yiq, 2yir, 2yit - hChk2 kinase domain + inhibitor
3i6u, 3i6w – hChk2 residues 84-502 (mutant)
