Casein kinase
From Proteopedia
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| + | {{STRUCTURE_3mb6| PDB=3mb6 | SIZE=400| SCENE= |right|CAPTION=Human casein kinase catalytic subunit complex with inhibitor, [[3mb6]] }} | ||
'''Casein kinase''' (CK) is a protein kinase which function as regulators of signal transduction. CK1 is a serine/threonine kinase with several members: a, b1, g1, g2, g3, d and e. CK2 functions in cell cycle control, DNA repair and circadian rhythm regulation. CK2 is a tetramer with a pair of 2 subunits – the a subunit is the catalytic one and the b subunit is the regulatory one. | '''Casein kinase''' (CK) is a protein kinase which function as regulators of signal transduction. CK1 is a serine/threonine kinase with several members: a, b1, g1, g2, g3, d and e. CK2 functions in cell cycle control, DNA repair and circadian rhythm regulation. CK2 is a tetramer with a pair of 2 subunits – the a subunit is the catalytic one and the b subunit is the regulatory one. | ||
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| + | == 3D Structures of casein kinase == | ||
===CK1=== | ===CK1=== | ||
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[[1ds5]] - mCK2 a subunit + b subunit peptide | [[1ds5]] - mCK2 a subunit + b subunit peptide | ||
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Revision as of 22:59, 14 October 2011
Casein kinase (CK) is a protein kinase which function as regulators of signal transduction. CK1 is a serine/threonine kinase with several members: a, b1, g1, g2, g3, d and e. CK2 functions in cell cycle control, DNA repair and circadian rhythm regulation. CK2 is a tetramer with a pair of 2 subunits – the a subunit is the catalytic one and the b subunit is the regulatory one.
Contents |
3D Structures of casein kinase
CK1
2c47 – hCK1-g2 – human
2chl - hCK1-g3
2cmw – hCK1-g1 + inhibitor
2izr, 2izs, 2izs, 2izu - hCK1-g3 + inhibitor
1cki – rCK1-d (mutant) – rat
1ckj - rCK1-d (mutant) + WO4
1csn – yCK1 + MgATP – fission yeast
2csn, 1eh4 – yCK1 catalytic domain + inhibitor
CK2 catalytic subunit
1pjk - hCK2 a subunit
1na7, 3fwq, 3juh - hCK2 a subunit (mutant)
3ofm - hCK2 a’ subunit
2r7i - rCK2 a subunit
1lpu, 1lr4, 1jam - mCK2 a subunit
CK2 catalytic subunit binary complex
2pvr - hCK2 a subunit + sulfate
3rp0 – hCK2 a subunit + a’ subunit + ATP analog
3bqc, 3c13 - hCK2 a subunit + emodin
1j91 - mCK2 a subunit + ATP competitive inhibitor - maize
1lp4 - mCK2 a subunit + Mg-AMPPNP
3nsz - hCK2 a subunit + AMPPN
1m2p, 1m2q, 1m2r, 1om1, 2oxd, 2oxx, 2oxy, 2qc6, 2pvh, 3fl5, 3kxg, 3kxh, 3kxm, 3kxn, 3pvg - mCK2 a subunit + inhibitor
3e3b, 2zjw, 3h30, 3mb6, 3mb7, 3nga, 3rps, 3pe1, 3pe2, 3amy - hCK2 a subunit + inhibitor
2pvh, 2pvj, 2pvk, 2pvl, 2pvm, 2pvn, 3be9 - mCK2 a subunit (mutant) + inhibitor
CK2 regulatory subunit
2r6m - rCK2 b subunit
1rqf - CK2 b subunit + cyclin-dependent kinase peptide – Xenopus laevis
CK2 catalytic + regulatory subunits
1jwh - hCK2 a subunit + b subunit
1ds5 - mCK2 a subunit + b subunit peptide
