1h57
From Proteopedia
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| - | [[Image:1h57.jpg|left|200px]]<br /><applet load="1h57" size=" | + | [[Image:1h57.jpg|left|200px]]<br /><applet load="1h57" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1h57, resolution 1.60Å" /> | caption="1h57, resolution 1.60Å" /> | ||
'''STRUCTURE OF HORSERADISH PEROXIDASE C1A COMPOUND III'''<br /> | '''STRUCTURE OF HORSERADISH PEROXIDASE C1A COMPOUND III'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1H57 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Armoracia_rusticana Armoracia rusticana] with ACT, CA, HEM, OXY and PEO as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] Known structural/functional Site: <scene name='pdbsite=CAA:Peo Binding Site For Chain A'>CAA</scene>. Full crystallographic information is available from [http:// | + | 1H57 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Armoracia_rusticana Armoracia rusticana] with <scene name='pdbligand=ACT:'>ACT</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=HEM:'>HEM</scene>, <scene name='pdbligand=OXY:'>OXY</scene> and <scene name='pdbligand=PEO:'>PEO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] Known structural/functional Site: <scene name='pdbsite=CAA:Peo+Binding+Site+For+Chain+A'>CAA</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H57 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: peroxidase]] | [[Category: peroxidase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:46:32 2008'' |
Revision as of 07:46, 3 February 2008
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STRUCTURE OF HORSERADISH PEROXIDASE C1A COMPOUND III
Overview
A molecular description of oxygen and peroxide activation in biological, systems is difficult, because electrons liberated during X-ray data, collection reduce the active centres of redox enzymes catalysing these, reactions. Here we describe an effective strategy to obtain crystal, structures for high-valency redox intermediates and present a, three-dimensional movie of the X-ray-driven catalytic reduction of a bound, dioxygen species in horseradish peroxidase (HRP). We also describe, separate experiments in which high-resolution structures could be obtained, for all five oxidation states of HRP, showing such structures with, preserved redox states for the first time.
About this Structure
1H57 is a Single protein structure of sequence from Armoracia rusticana with , , , and as ligands. Active as Peroxidase, with EC number 1.11.1.7 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The catalytic pathway of horseradish peroxidase at high resolution., Berglund GI, Carlsson GH, Smith AT, Szoke H, Henriksen A, Hajdu J, Nature. 2002 May 23;417(6887):463-8. PMID:12024218
Page seeded by OCA on Sun Feb 3 09:46:32 2008
Categories: Armoracia rusticana | Peroxidase | Single protein | Berglund, G.I. | Carlsson, G.H. | Hajdu, J. | Henriksen, A. | Smith, A.T. | Szoke, H. | ACT | CA | HEM | OXY | PEO | Catalytic intermediate | Compound iii | Horseradish | Oxidoreductase | Oxyperoxidase
