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2xwy
From Proteopedia
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| - | + | [[Image:2xwy.png|left|200px]] | |
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===STRUCTURE OF MK-3281, A POTENT NON-NUCLEOSIDE FINGER-LOOP INHIBITOR, IN COMPLEX WITH THE HEPATITIS C VIRUS NS5B POLYMERASE=== | ===STRUCTURE OF MK-3281, A POTENT NON-NUCLEOSIDE FINGER-LOOP INHIBITOR, IN COMPLEX WITH THE HEPATITIS C VIRUS NS5B POLYMERASE=== | ||
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| + | The line below this paragraph, {{ABSTRACT_PUBMED_21141896}}, adds the Publication Abstract to the page | ||
| + | (as it appears on PubMed at http://www.pubmed.gov), where 21141896 is the PubMed ID number. | ||
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| + | {{ABSTRACT_PUBMED_21141896}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2xwy]] is a 1 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWY OCA]. | |
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| + | ==See Also== | ||
| + | *[[RNA polymerase]] | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:021141896</ref><references group="xtra"/> | ||
[[Category: Hepatitis c virus]] | [[Category: Hepatitis c virus]] | ||
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
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[[Category: Nucleotidyltransferase]] | [[Category: Nucleotidyltransferase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 22 09:51:07 2010'' | ||
Revision as of 07:18, 30 October 2011
Contents |
STRUCTURE OF MK-3281, A POTENT NON-NUCLEOSIDE FINGER-LOOP INHIBITOR, IN COMPLEX WITH THE HEPATITIS C VIRUS NS5B POLYMERASE
Template:ABSTRACT PUBMED 21141896
About this Structure
2xwy is a 1 chain structure of RNA polymerase with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
See Also
Reference
- Narjes F, Crescenzi B, Ferrara M, Habermann J, Colarusso S, Ferreira Mdel R, Stansfield I, Mackay AC, Conte I, Ercolani C, Zaramella S, Palumbi MC, Meuleman P, Leroux-Roels G, Giuliano C, Fiore F, Di Marco S, Baiocco P, Koch U, Migliaccio G, Altamura S, Laufer R, De Francesco R, Rowley M. Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase. J Med Chem. 2011 Jan 13;54(1):289-301. Epub 2010 Dec 8. PMID:21141896 doi:10.1021/jm1013105
