3sqy

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Revision as of 07:23, 30 October 2011

Template:STRUCTURE 3sqy

S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines

Template:ABSTRACT PUBMED 21831637

About this Structure

3sqy is a 1 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

• Li X, Hilgers M, Cunningham M, Chen Z, Trzoss M, Zhang J, Kohnen L, Lam T, Creighton C, Gc K, Nelson K, Kwan B, Stidham M, Brown-Driver V, Shaw KJ, Finn J. Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5171-6. Epub 2011 Jul 23. PMID:21831637 doi:10.1016/j.bmcl.2011.07.059