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1h8p
From Proteopedia
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| - | [[Image:1h8p.jpg|left|200px]]<br /><applet load="1h8p" size=" | + | [[Image:1h8p.jpg|left|200px]]<br /><applet load="1h8p" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1h8p, resolution 1.82Å" /> | caption="1h8p, resolution 1.82Å" /> | ||
'''BULL SEMINAL PLASMA PDC-109 FIBRONECTIN TYPE II MODULE'''<br /> | '''BULL SEMINAL PLASMA PDC-109 FIBRONECTIN TYPE II MODULE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1H8P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with PC as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Poc Binding Site For Residue A1111'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1H8P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=PC:'>PC</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Poc+Binding+Site+For+Residue+A1111'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8P OCA]. |
==Reference== | ==Reference== | ||
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[[Category: phosphorylcholine-binding protein]] | [[Category: phosphorylcholine-binding protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:47:44 2008'' |
Revision as of 07:47, 3 February 2008
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BULL SEMINAL PLASMA PDC-109 FIBRONECTIN TYPE II MODULE
Overview
Bovine seminal plasma PDC-109 binds to sperm surface choline lipids and, promotes sperm capacitation by stimulating the efflux of cholesterol and, phospholipids. The structure of PDC-109 with bound phosphorylcholine was, solved using MAD data of a single platinum site. Its two globular (40 x 50, x 20 A(3)) Fn2 domains are linked and clustered by a short polypeptide., The choline binding sites lie at the same face of the molecule., Phosphorylcholine binds to the Fn2 domains through a cation-pi interaction, between the quaternary ammonium group and a core tryptophan, plus hydrogen, bonding between hydroxyls of exposed tyrosines and the phosphate group., The structure of the PDC-109-oPC complex provides a structural ground for, the sperm membrane-coating mechanism underlying PDC-109-induced, capacitation.
About this Structure
1H8P is a Single protein structure of sequence from Bos taurus with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Sperm coating mechanism from the 1.8 A crystal structure of PDC-109-phosphorylcholine complex., Wah DA, Fernandez-Tornero C, Sanz L, Romero A, Calvete JJ, Structure. 2002 Apr;10(4):505-14. PMID:11937055
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