1hkx
From Proteopedia
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| - | [[Image:1hkx.gif|left|200px]]<br /><applet load="1hkx" size=" | + | [[Image:1hkx.gif|left|200px]]<br /><applet load="1hkx" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1hkx, resolution 2.65Å" /> | caption="1hkx, resolution 2.65Å" /> | ||
'''CRYSTAL STRUCTURE OF CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE'''<br /> | '''CRYSTAL STRUCTURE OF CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HKX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with CL, DTT and TBR as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.17 Transferred entry: 2.7.11.17], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.123 2.7.1.123] Known structural/functional Site: <scene name='pdbsite=AC1:Cl Binding Site For Chain N'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1HKX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=DTT:'>DTT</scene> and <scene name='pdbligand=TBR:'>TBR</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.17 Transferred entry: 2.7.11.17], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.123 2.7.1.123] Known structural/functional Site: <scene name='pdbsite=AC1:Cl+Binding+Site+For+Chain+N'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKX OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:50:01 2008'' |
Revision as of 07:50, 3 February 2008
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CRYSTAL STRUCTURE OF CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE
Overview
We report the crystal structure of the 143 residue association domain of, Ca(2+)/calmodulin-dependent protein kinase II (CaMKII). The association, domain forms a hub-like assembly, composed of two rings of seven protomers, each, which are stacked head to head and held together by extensive, interfaces. The tetradecameric organization of the assembly was confirmed, by analytical ultracentrifugation and multiangle light scattering., Individual protomers form wedge-shaped structures from which N-terminal, helical segments that connect to the kinase domain extend toward the, equatorial plane of the assembly, consistent with the arrangement of the, kinase domains in a second outer ring. A deep and highly conserved pocket, present within the association domain may serve as a docking site for, proteins that interact with CaMKII.
About this Structure
1HKX is a Single protein structure of sequence from Mus musculus with , and as ligands. Active as Transferred entry: 2.7.11.17, with EC number 2.7.1.123 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II., Hoelz A, Nairn AC, Kuriyan J, Mol Cell. 2003 May;11(5):1241-51. PMID:12769848
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