1hsr
From Proteopedia
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| - | [[Image:1hsr.gif|left|200px]]<br /><applet load="1hsr" size=" | + | [[Image:1hsr.gif|left|200px]]<br /><applet load="1hsr" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1hsr, resolution 1.60Å" /> | caption="1hsr, resolution 1.60Å" /> | ||
'''BINDING MODE OF BENZHYDROXAMIC ACID TO ARTHROMYCES RAMOSUS PEROXIDASE'''<br /> | '''BINDING MODE OF BENZHYDROXAMIC ACID TO ARTHROMYCES RAMOSUS PEROXIDASE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HSR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Eukaryota Eukaryota] with CA, HEM and BHO as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] Known structural/functional Sites: <scene name='pdbsite=CA1:Active Site'>CA1</scene>, <scene name='pdbsite=CA2:Active Site'>CA2</scene> and <scene name='pdbsite=GL1:Active Site'>GL1</scene>. Full crystallographic information is available from [http:// | + | 1HSR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Eukaryota Eukaryota] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=BHO:'>BHO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] Known structural/functional Sites: <scene name='pdbsite=CA1:Active+Site'>CA1</scene>, <scene name='pdbsite=CA2:Active+Site'>CA2</scene> and <scene name='pdbsite=GL1:Active+Site'>GL1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HSR OCA]. |
==Reference== | ==Reference== | ||
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[[Category: peroxidase]] | [[Category: peroxidase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:50:14 2008'' |
Revision as of 07:50, 3 February 2008
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BINDING MODE OF BENZHYDROXAMIC ACID TO ARTHROMYCES RAMOSUS PEROXIDASE
Overview
The crystal structure of Arthromyces ramosus peroxidase (ARP) in complex, with benzhydroxamic acid (BHA) as determined by X-ray analysis at 1.6 A, shows unambiguously how BHA binds to ARP. BHA is located in the distal, heme pocket. Its functional groups are held by three hydrogen bonds to, His56N(epsilon), Arg52N(epsilon), and Pro(154)O, but are too far away to, interact with the heme iron. The aromatic ring of BHA is positioned at the, entrance of the channel to the heme pocket, approximately parallel to the, heme group. Most water molecules at the active site of the native enzyme, are replaced by BHA, leaving a ligand, probably a water molecule, at the, sixth position of the heme. Results are compared with spectroscopic data.
About this Structure
1HSR is a Single protein structure of sequence from Eukaryota with , and as ligands. Active as Peroxidase, with EC number 1.11.1.7 Known structural/functional Sites: , and . Full crystallographic information is available from OCA.
Reference
Binding mode of benzhydroxamic acid to Arthromyces ramosus peroxidase shown by X-ray crystallographic analysis of the complex at 1.6 A resolution., Itakura H, Oda Y, Fukuyama K, FEBS Lett. 1997 Jul 21;412(1):107-10. PMID:9257700
Page seeded by OCA on Sun Feb 3 09:50:14 2008
Categories: Eukaryota | Peroxidase | Single protein | Fukuyama, K. | Itakura, H. | BHO | CA | HEM | Glycoprotein | Oxidoreductase
