1kct
From Proteopedia
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| - | [[Image:1kct.jpg|left|200px]]<br /><applet load="1kct" size=" | + | [[Image:1kct.jpg|left|200px]]<br /><applet load="1kct" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1kct, resolution 3.46Å" /> | caption="1kct, resolution 3.46Å" /> | ||
'''ALPHA1-ANTITRYPSIN'''<br /> | '''ALPHA1-ANTITRYPSIN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1KCT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Known structural/functional Site: <scene name='pdbsite=P1:Reactive Site In Inhibitory Loop'>P1</scene>. Full crystallographic information is available from [http:// | + | 1KCT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Known structural/functional Site: <scene name='pdbsite=P1:Reactive+Site+In+Inhibitory+Loop'>P1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCT OCA]. |
==Reference== | ==Reference== | ||
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[[Category: serpin]] | [[Category: serpin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:51:10 2008'' |
Revision as of 07:51, 3 February 2008
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ALPHA1-ANTITRYPSIN
Contents |
Overview
The crystal structure of a recombinant human alpha 1-antitrypsin, in the, uncleaved and uncomplexed state, has been determined by X-ray, crystallographic methods and refined to an R-factor of 18.4% for 8.0-3.46, A data with good stereochemistry. This structure provides the first view, at the inhibitory loop and the central beta-sheet A of the uncleaved alpha, 1-antitrypsin. The reactive loop takes a distorted helical conformation, and no pre-insertion of two residues in the reactive loop into the, beta-sheet A is observed. The present structure is largely in agreement, with the model predicted by Engh, Wright, and Huber [Prot. Eng. 3 (1990), 469-477].
Disease
Known diseases associated with this structure: Emphysema OMIM:[107400], Emphysema-cirrhosis OMIM:[107400], Hemorrhagic diathesis due to antithrombin Pittsburgh OMIM:[107400], Pulmonary disease, chronic obstructive, susceptibility to OMIM:[107400]
About this Structure
1KCT is a Single protein structure of sequence from Homo sapiens. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of an uncleaved alpha 1-antitrypsin reveals the conformation of its inhibitory reactive loop., Song HK, Lee KN, Kwon KS, Yu MH, Suh SW, FEBS Lett. 1995 Dec 18;377(2):150-4. PMID:8543039
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