1ah1
From Proteopedia
(New page: 200px<br /> <applet load="1ah1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ah1" /> '''CTLA-4, NMR, 20 STRUCTURES'''<br /> ==Over...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1AH1 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AH1 OCA]]. | + | 1AH1 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Structure known Active Sites: GL1 and GL2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AH1 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: t cell receptor]] | [[Category: t cell receptor]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:34:20 2007'' |
Revision as of 10:29, 30 October 2007
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CTLA-4, NMR, 20 STRUCTURES
Overview
The structure of human CTLA-4 reveals that residues Met 99, Tyr 100 and, Tyr 104 of the M99YPPPY104 motif are adjacent to a patch of charged, surface residues on the A'GFCC' face of the protein. Mutation of these, residues, which are conserved in the CTLA-4/CD28 family, significantly, reduces binding to CD80 and/or CD86, implicating this patch as a ligand, binding site.
About this Structure
1AH1 is a [Single protein] structure of sequence from [Homo sapiens]. Structure known Active Sites: GL1 and GL2. Full crystallographic information is available from [OCA].
Reference
Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28., Metzler WJ, Bajorath J, Fenderson W, Shaw SY, Constantine KL, Naemura J, Leytze G, Peach RJ, Lavoie TB, Mueller L, Linsley PS, Nat Struct Biol. 1997 Jul;4(7):527-31. PMID:9228944
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