1oax
From Proteopedia
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| - | [[Image:1oax.jpg|left|200px]]<br /><applet load="1oax" size=" | + | [[Image:1oax.jpg|left|200px]]<br /><applet load="1oax" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1oax, resolution 2.67Å" /> | caption="1oax, resolution 2.67Å" /> | ||
'''FV STRUCTURE OF THE IGE SPE-7 IN COMPLEX WITH ACENAPHTHENEQUINONE'''<br /> | '''FV STRUCTURE OF THE IGE SPE-7 IN COMPLEX WITH ACENAPHTHENEQUINONE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1OAX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus] with ANQ as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Anq Binding Site For Chain J'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1OAX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus] with <scene name='pdbligand=ANQ:'>ANQ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Anq+Binding+Site+For+Chain+J'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAX OCA]. |
==Reference== | ==Reference== | ||
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[[Category: ige]] | [[Category: ige]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:55:42 2008'' |
Revision as of 07:55, 3 February 2008
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FV STRUCTURE OF THE IGE SPE-7 IN COMPLEX WITH ACENAPHTHENEQUINONE
Overview
A single antibody was shown to adopt different binding-site conformations, and thereby bind unrelated antigens. Analysis by both x-ray, crystallography and pre-steady-state kinetics revealed an equilibrium, between different preexisting isomers, one of which possessed a, promiscuous, low-affinity binding site for aromatic ligands, including the, immunizing hapten. A subsequent induced-fit isomerization led to, high-affinity complexes with a deep and narrow binding site. A protein, antigen identified by repertoire selection made use of an unrelated, antibody isomer with a wide, shallow binding site. Conformational, diversity, whereby one sequence adopts multiple structures and multiple, functions, can increase the effective size of the antibody repertoire but, may also lead to autoimmunity and allergy.
About this Structure
1OAX is a Protein complex structure of sequences from Rattus rattus with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Antibody multispecificity mediated by conformational diversity., James LC, Roversi P, Tawfik DS, Science. 2003 Feb 28;299(5611):1362-7. PMID:12610298
Page seeded by OCA on Sun Feb 3 09:55:42 2008
Categories: Protein complex | Rattus rattus | James, L.C. | Roversi, P. | Tawfik, D. | ANQ | Allergy | Antibody | Ige
