1hj7

From Proteopedia

Revision as of 10:29, 30 October 2007

NMR STUDY OF A PAIR OF LDL RECEPTOR CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, 20 STRUCTURES

Overview

BACKGROUND: From the observed structure and sequence of a pair of calcium, binding (cb) epidermal growth factor-like (EGF) domains from human, fibrillin-1, we proposed that many tandem cbEGF domains adopt a conserved, relative conformation. The low-density lipoprotein receptor (LDLR), which, is functionally unrelated to fibrillin-1, contains a single pair of EGF, domains that was chosen for study in the validation of this hypothesis., The LDLR is the protein that is defective in familial, hypercholesterolaemia, a common genetic disorder that predisposes, individuals to cardiovascular complications and premature death. RESULTS:, Here, we present the solution structure of the first two EGF domains from, the LDL receptor, determined using conventional NMR restraints and, residual dipolar ... [(full description)]

About this Structure

1HJ7 is a [Single protein] structure of sequence from [Homo sapiens] with CA as [ligand]. Structure known Active Sites: CA1 and CA2. Full crystallographic information is available from [OCA].

Reference

Solution structure of the LDL receptor EGF-AB pair: a paradigm for the assembly of tandem calcium binding EGF domains., Saha S, Boyd J, Werner JM, Knott V, Handford PA, Campbell ID, Downing AK, Structure. 2001 Jun;9(6):451-6. PMID:11435110

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