1ocn
From Proteopedia
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| - | [[Image:1ocn.jpg|left|200px]]<br /><applet load="1ocn" size=" | + | [[Image:1ocn.jpg|left|200px]]<br /><applet load="1ocn" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ocn, resolution 1.31Å" /> | caption="1ocn, resolution 1.31Å" /> | ||
'''MUTANT D416A OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH A CELLOBIO-DERIVED ISOFAGOMINE AT 1.3 ANGSTROM RESOLUTION'''<br /> | '''MUTANT D416A OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH A CELLOBIO-DERIVED ISOFAGOMINE AT 1.3 ANGSTROM RESOLUTION'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1OCN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Humicola_insolens Humicola insolens] with NAG, BGC, CA and IFM as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] Known structural/functional Site: <scene name='pdbsite=ACI:Ca Binding Site For Chain A'>ACI</scene>. Full crystallographic information is available from [http:// | + | 1OCN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Humicola_insolens Humicola insolens] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=BGC:'>BGC</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=IFM:'>IFM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] Known structural/functional Site: <scene name='pdbsite=ACI:Ca+Binding+Site+For+Chain+A'>ACI</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OCN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:56:11 2008'' |
Revision as of 07:56, 3 February 2008
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MUTANT D416A OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH A CELLOBIO-DERIVED ISOFAGOMINE AT 1.3 ANGSTROM RESOLUTION
Overview
A cellobio-derived isofagomine glycosidase inhibitor (Ki approximately 400, nM) displays an unusual distorted 2,5B (boat) conformation upon binding to, cellobiohydrolase Cel6A from Humicola insolens, highlighting the different, conformational itineraries used by various glycosidases, with consequences, for the design of therapeutic agents.
About this Structure
1OCN is a Single protein structure of sequence from Humicola insolens with , , and as ligands. Active as Cellulose 1,4-beta-cellobiosidase, with EC number 3.2.1.91 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting beta-glucosidases., Varrot A, Macdonald J, Stick RV, Pell G, Gilbert HJ, Davies GJ, Chem Commun (Camb). 2003 Apr 21;(8):946-7. PMID:12744312
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