1od8
From Proteopedia
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| - | [[Image:1od8.jpg|left|200px]]<br /><applet load="1od8" size=" | + | [[Image:1od8.jpg|left|200px]]<br /><applet load="1od8" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1od8, resolution 1.05Å" /> | caption="1od8, resolution 1.05Å" /> | ||
'''XYLANASE XYN10A FROM STREPTOMYCES LIVIDANS IN COMPLEX WITH XYLOBIO-ISOFAGOMINE LACTAM'''<br /> | '''XYLANASE XYN10A FROM STREPTOMYCES LIVIDANS IN COMPLEX WITH XYLOBIO-ISOFAGOMINE LACTAM'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1OD8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans] with XYP, NA, XDL and IMD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Endo-1,4-beta-xylanase Endo-1,4-beta-xylanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8] Known structural/functional Site: <scene name='pdbsite=AC1:Xys Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1OD8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans] with <scene name='pdbligand=XYP:'>XYP</scene>, <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=XDL:'>XDL</scene> and <scene name='pdbligand=IMD:'>IMD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Endo-1,4-beta-xylanase Endo-1,4-beta-xylanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8] Known structural/functional Site: <scene name='pdbsite=AC1:Xys+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD8 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: xylanase]] | [[Category: xylanase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:56:25 2008'' |
Revision as of 07:56, 3 February 2008
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XYLANASE XYN10A FROM STREPTOMYCES LIVIDANS IN COMPLEX WITH XYLOBIO-ISOFAGOMINE LACTAM
Overview
The atomic-resolution structure of a xylobiose-derived isofagomine lactam, in complex with the xylanase Xyn10A from Streptomyces lividans reveals, that the lactam is bound to the enzyme as the amide tautomer, with, "reversed" protonation-states for nucleophile and acid-base.
About this Structure
1OD8 is a Single protein structure of sequence from Streptomyces lividans with , , and as ligands. Active as Endo-1,4-beta-xylanase, with EC number 3.2.1.8 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer., Gloster T, Williams SJ, Tarling CA, Roberts S, Dupont C, Jodoin P, Shareck F, Withers SG, Davies GJ, Chem Commun (Camb). 2003 Apr 21;(8):944-5. PMID:12744311
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