1oge
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1oge.gif|left|200px]]<br /><applet load="1oge" size=" | + | [[Image:1oge.gif|left|200px]]<br /><applet load="1oge" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1oge, resolution 2.05Å" /> | caption="1oge, resolution 2.05Å" /> | ||
'''THE STRUCTURE OF BACILLUS SUBTILIS RBSD COMPLEXED WITH RIBOSE 5-PHOSPHATE'''<br /> | '''THE STRUCTURE OF BACILLUS SUBTILIS RBSD COMPLEXED WITH RIBOSE 5-PHOSPHATE'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1OGE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with CL and RP5 as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Rp5 Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1OGE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=RP5:'>RP5</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Rp5+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OGE OCA]. |
==Reference== | ==Reference== | ||
| Line 21: | Line 21: | ||
[[Category: transport]] | [[Category: transport]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:57:46 2008'' |
Revision as of 07:57, 3 February 2008
|
THE STRUCTURE OF BACILLUS SUBTILIS RBSD COMPLEXED WITH RIBOSE 5-PHOSPHATE
Overview
RbsD is the only protein whose biochemical function is unknown among the, six gene products of the rbs operon involved in the active transport of, ribose. FucU, a paralogue of RbsD conserved from bacteria to human, is, also the only protein whose function is unknown among the seven gene, products of the l-fucose regulon. Here we report the crystal structures of, Bacillus subtilis RbsD, which reveals a novel decameric toroidal assembly, of the protein. Nuclear magnetic resonance and other studies on RbsD, reveal that the intersubunit cleft of the protein binds specific forms of, d-ribose, but it does not have an enzyme activity toward the sugar., Likewise, FucU binds l-fucose but lacks an enzyme activity toward this, sugar. We conclude that RbsD and FucU are cytoplasmic sugar-binding, proteins, a novel class of proteins whose functional role may lie in, helping influx of the sugar substrates.
About this Structure
1OGE is a Single protein structure of sequence from Bacillus subtilis with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structures of RbsD leading to the identification of cytoplasmic sugar-binding proteins with a novel folding architecture., Kim MS, Shin J, Lee W, Lee HS, Oh BH, J Biol Chem. 2003 Jul 25;278(30):28173-80. Epub 2003 May 8. PMID:12738765
Page seeded by OCA on Sun Feb 3 09:57:46 2008
