1ogq
From Proteopedia
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| - | [[Image:1ogq.jpg|left|200px]]<br /><applet load="1ogq" size=" | + | [[Image:1ogq.jpg|left|200px]]<br /><applet load="1ogq" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ogq, resolution 1.7Å" /> | caption="1ogq, resolution 1.7Å" /> | ||
'''THE CRYSTAL STRUCTURE OF PGIP (POLYGALACTURONASE INHIBITING PROTEIN), A LEUCINE RICH REPEAT PROTEIN INVOLVED IN PLANT DEFENSE'''<br /> | '''THE CRYSTAL STRUCTURE OF PGIP (POLYGALACTURONASE INHIBITING PROTEIN), A LEUCINE RICH REPEAT PROTEIN INVOLVED IN PLANT DEFENSE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1OGQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Phaseolus_vulgaris Phaseolus vulgaris] with NAG and ACT as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Act Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1OGQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Phaseolus_vulgaris Phaseolus vulgaris] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=ACT:'>ACT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Act+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OGQ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: polygalacturonase inhibiting protein]] | [[Category: polygalacturonase inhibiting protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:57:54 2008'' |
Revision as of 07:57, 3 February 2008
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THE CRYSTAL STRUCTURE OF PGIP (POLYGALACTURONASE INHIBITING PROTEIN), A LEUCINE RICH REPEAT PROTEIN INVOLVED IN PLANT DEFENSE
Overview
Polygalacturonase-inhibiting proteins (PGIPs) are plant cell wall proteins, that protect plants from fungal invasion. They interact with, endopolygalacturonases secreted by phytopathogenic fungi, inhibit their, enzymatic activity, and favor the accumulation of oligogalacturonides, which activate plant defense responses. PGIPs are members of the, leucine-rich repeat (LRR) protein family that in plants play crucial roles, in development, defense against pathogens, and recognition of beneficial, microbes. Here we report the crystal structure at 1.7-A resolution of a, PGIP from Phaseolus vulgaris. The structure is characterized by the, presence of two beta-sheets instead of the single one originally predicted, by modeling studies. The structure also reveals a negatively charged, surface on the LRR concave face, likely involved in binding, polygalacturonases. The structural information on PGIP provides a basis, for designing more efficient inhibitors for plant protection.
About this Structure
1OGQ is a Single protein structure of sequence from Phaseolus vulgaris with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The crystal structure of polygalacturonase-inhibiting protein (PGIP), a leucine-rich repeat protein involved in plant defense., Di Matteo A, Federici L, Mattei B, Salvi G, Johnson KA, Savino C, De Lorenzo G, Tsernoglou D, Cervone F, Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10124-8. Epub 2003 Aug 6. PMID:12904578
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