1oht
From Proteopedia
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| - | [[Image:1oht.gif|left|200px]]<br /><applet load="1oht" size=" | + | [[Image:1oht.gif|left|200px]]<br /><applet load="1oht" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1oht, resolution 2.0Å" /> | caption="1oht, resolution 2.0Å" /> | ||
'''PEPTIDOGLYCAN RECOGNITION PROTEIN-LB'''<br /> | '''PEPTIDOGLYCAN RECOGNITION PROTEIN-LB'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1OHT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with ZN, EDO and TLA as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Tla Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1OHT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=EDO:'>EDO</scene> and <scene name='pdbligand=TLA:'>TLA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Tla+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OHT OCA]. |
==Reference== | ==Reference== | ||
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[[Category: peptidoglycan-recognition protein-lb isoform 2]] | [[Category: peptidoglycan-recognition protein-lb isoform 2]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:58:17 2008'' |
Revision as of 07:58, 3 February 2008
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PEPTIDOGLYCAN RECOGNITION PROTEIN-LB
Overview
The family of peptidoglycan recognition proteins (PGRPs) are associated, with the recognition of the peptidoglycan of microbes and subsequent, activation of signaling pathways for immune response. Here the crystal, structure of Drosophila PGRP-LB is determined at a resolution of 2.0 A and, shows an active-site cleft with a zinc cage. Poor conservation of surface, residues at the cleft predicts a widely varying individual specificity of, PGRPs for molecular patterns on microbial cell walls. At the back of this, cleft is a putatively conserved distinctive groove. The location and, mainly hydrophobic nature of the groove indicate that the back face serves, for subsequent signaling after clustering of PGRP molecules by binding to, polymeric cell wall components.
About this Structure
1OHT is a Single protein structure of sequence from Drosophila melanogaster with , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster., Kim MS, Byun M, Oh BH, Nat Immunol. 2003 Aug;4(8):787-93. Epub 2003 Jul 6. PMID:12845326
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