1vrk
From Proteopedia
(New page: 200px<br /> <applet load="1vrk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vrk, resolution 1.90Å" /> '''THE 1.9 ANGSTROM ST...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1VRK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]] with CA, ACT and NH2 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.117 2.7.1.117]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VRK OCA]]. | + | 1VRK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]] with CA, ACT and NH2 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.18 Transferred entry: 2.7.11.18]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.117 2.7.1.117]]. Structure known Active Sites: CA1, CA2, CA3 and CA4. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VRK OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Synthetic construct]] | [[Category: Synthetic construct]] | ||
| + | [[Category: Transferred entry: 2.7.11.18]] | ||
[[Category: Anderson, W.F.]] | [[Category: Anderson, W.F.]] | ||
[[Category: Weigand, S.]] | [[Category: Weigand, S.]] | ||
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[[Category: signalling]] | [[Category: signalling]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:35:31 2007'' |
Revision as of 10:30, 30 October 2007
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THE 1.9 ANGSTROM STRUCTURE OF E84K-CALMODULIN RS20 PEPTIDE COMPLEX
Overview
The enhancement of calmodulin's (CaM) calcium binding activity by an, enzyme or a recognition site peptide and its diminution by key point, mutations at the protein recognition interface (e.g., E84K-CaM), which is, more than 20 A away from the nearest calcium ligation structure, can be, described by an expanded version of the Adair-Klotz equation for, multiligand binding. The expanded equation can accurately describe the, calcium binding events and their variable linkage to protein recognition, events can be extended to other CaM-regulated enzymes and can potentially, be applied to a diverse array of ligand binding systems with allosteric, regulation of ligand binding, whether by other ligands or protein, interaction. The 1.9 A resolution X-ray crystallographic structure of the, complex ... [(full description)]
About this Structure
1VRK is a [Single protein] structure of sequence from [Synthetic construct] with CA, ACT and NH2 as [ligands]. Active as [Transferred entry: 2.7.11.18], with EC number [2.7.1.117]. Structure known Active Sites: CA1, CA2, CA3 and CA4. Full crystallographic information is available from [OCA].
Reference
Analysis of the functional coupling between calmodulin's calcium binding and peptide recognition properties., Mirzoeva S, Weigand S, Lukas TJ, Shuvalova L, Anderson WF, Watterson DM, Biochemistry. 1999 Mar 30;38(13):3936-47. PMID:10194305
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