1okc
From Proteopedia
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| - | [[Image:1okc.gif|left|200px]]<br /><applet load="1okc" size=" | + | [[Image:1okc.gif|left|200px]]<br /><applet load="1okc" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1okc, resolution 2.20Å" /> | caption="1okc, resolution 2.20Å" /> | ||
'''STRUCTURE OF MITOCHONDRIAL ADP/ATP CARRIER IN COMPLEX WITH CARBOXYATRACTYLOSIDE'''<br /> | '''STRUCTURE OF MITOCHONDRIAL ADP/ATP CARRIER IN COMPLEX WITH CARBOXYATRACTYLOSIDE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1OKC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with CXT, CDL, LDM and PC1 as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Pc2 Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1OKC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=CXT:'>CXT</scene>, <scene name='pdbligand=CDL:'>CDL</scene>, <scene name='pdbligand=LDM:'>LDM</scene> and <scene name='pdbligand=PC1:'>PC1</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Pc2+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OKC OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transport]] | [[Category: transport]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:59:14 2008'' |
Revision as of 07:59, 3 February 2008
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STRUCTURE OF MITOCHONDRIAL ADP/ATP CARRIER IN COMPLEX WITH CARBOXYATRACTYLOSIDE
Overview
ATP, the principal energy currency of the cell, fuels most biosynthetic, reactions in the cytoplasm by its hydrolysis into ADP and inorganic, phosphate. Because resynthesis of ATP occurs in the mitochondrial matrix, ATP is exported into the cytoplasm while ADP is imported into the matrix., The exchange is accomplished by a single protein, the ADP/ATP carrier., Here we have solved the bovine carrier structure at a resolution of 2.2 A, by X-ray crystallography in complex with an inhibitor, carboxyatractyloside. Six alpha-helices form a compact transmembrane, domain, which, at the surface towards the space between inner and outer, mitochondrial membranes, reveals a deep depression. At its bottom, a, hexapeptide carrying the signature of nucleotide carriers (RRRMMM) is, located. Our structure, together with earlier biochemical results, suggests that transport substrates bind to the bottom of the cavity and, that translocation results from a transient transition from a 'pit' to a, 'channel' conformation.
About this Structure
1OKC is a Single protein structure of sequence from Bos taurus with , , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside., Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, Trezeguet V, Lauquin GJ, Brandolin G, Nature. 2003 Nov 6;426(6962):39-44. PMID:14603310
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