1oke
From Proteopedia
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| - | [[Image:1oke.gif|left|200px]]<br /><applet load="1oke" size=" | + | [[Image:1oke.gif|left|200px]]<br /><applet load="1oke" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1oke, resolution 2.4Å" /> | caption="1oke, resolution 2.4Å" /> | ||
'''CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN IN COMPLEX WITH N-OCTYL-BETA-D-GLUCOSIDE'''<br /> | '''CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN IN COMPLEX WITH N-OCTYL-BETA-D-GLUCOSIDE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1OKE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_type_3 Dengue virus type 3] with NAG and BOG as [http://en.wikipedia.org/wiki/ligands ligands]. This structure superseeds the now removed PDB entry 1OAM. Known structural/functional Site: <scene name='pdbsite=NG1:Bog Binding Site For Chain B'>NG1</scene>. Full crystallographic information is available from [http:// | + | 1OKE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_type_3 Dengue virus type 3] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=BOG:'>BOG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. This structure superseeds the now removed PDB entry 1OAM. Known structural/functional Site: <scene name='pdbsite=NG1:Bog+Binding+Site+For+Chain+B'>NG1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OKE OCA]. |
==Reference== | ==Reference== | ||
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[[Category: virus/viral protein]] | [[Category: virus/viral protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:59:15 2008'' |
Revision as of 07:59, 3 February 2008
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CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN IN COMPLEX WITH N-OCTYL-BETA-D-GLUCOSIDE
Overview
Dengue virus is an emerging global health threat. Its major envelope, glycoprotein, E, mediates viral attachment and entry by membrane fusion. A, crystal structure of the soluble ectodomain of E from dengue virus type 2, reveals a hydrophobic pocket lined by residues that influence the pH, threshold for fusion. The pocket, which accepts a hydrophobic ligand, opens and closes through a conformational shift in a beta-hairpin at the, interface between two domains. These features point to a structural, pathway for the fusion-activating transition and suggest a strategy for, finding small-molecule inhibitors of dengue and other flaviviruses.
About this Structure
1OKE is a Single protein structure of sequence from Dengue virus type 3 with and as ligands. This structure superseeds the now removed PDB entry 1OAM. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
A ligand-binding pocket in the dengue virus envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91. Epub 2003 May 20. PMID:12759475
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