3zyu

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'''Unreleased structure'''
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[[Image:3zyu.jpg|left|200px]]
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The entry 3zyu is ON HOLD until Paper Publication
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{{STRUCTURE_3zyu| PDB=3zyu | SCENE= }}
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Authors: Chung, C., Mirguet, O.
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===CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH I-BET151(GSK1210151A)===
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Description: Crystal Structure of the first bromodomain of human BRD4 in complex with I-BET151(GSK1210151A)
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{{ABSTRACT_PUBMED_21964340}}
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==About this Structure==
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[[3zyu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYU OCA].
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==Reference==
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<ref group="xtra">PMID:021964340</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Chung, C W.]]
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[[Category: Mirguet, O.]]
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[[Category: Bromodomain]]
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[[Category: Epigenetic reader]]
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[[Category: Histone]]
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[[Category: I-151]]
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[[Category: Inhibitor]]
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[[Category: Signaling protein]]

Revision as of 08:17, 2 November 2011

Image:3zyu.jpg

Template:STRUCTURE 3zyu

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH I-BET151(GSK1210151A)

Template:ABSTRACT PUBMED 21964340

About this Structure

3zyu is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, Robson SC, Chung CW, Hopf C, Savitski MM, Huthmacher C, Gudgin E, Lugo D, Beinke S, Chapman TD, Roberts EJ, Soden PE, Auger KR, Mirguet O, Doehner K, Delwel R, Burnett AK, Jeffrey P, Drewes G, Lee K, Huntly BJ, Kouzarides T. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 2011 Oct 2;478(7370):529-33. doi: 10.1038/nature10509. PMID:21964340 doi:10.1038/nature10509

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OCA

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