3tfq
From Proteopedia
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| + | {{STRUCTURE_3tfq| PDB=3tfq | SCENE= }} | ||
| - | + | ===Crystal structure of 11b-hsd1 double mutant (l262r, f278e) complexed with 8-{[(2-CYANOPYRIDIN-3-YL)METHYL]SULFANYL}-6-HYDROXY-3,4-DIHYDRO-1H-PYRANO[3,4-C]PYRIDINE-5-CARBONITRILE=== | |
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| + | The line below this paragraph, {{ABSTRACT_PUBMED_21983444}}, adds the Publication Abstract to the page | ||
| + | (as it appears on PubMed at http://www.pubmed.gov), where 21983444 is the PubMed ID number. | ||
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| + | {{ABSTRACT_PUBMED_21983444}} | ||
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| + | ==About this Structure== | ||
| + | [[3tfq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFQ OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:021983444</ref><references group="xtra"/> | ||
| + | [[Category: 11-beta-hydroxysteroid dehydrogenase]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Sheriff, S.]] | ||
| + | [[Category: 11b-hsd1]] | ||
| + | [[Category: Dehydrogenase]] | ||
| + | [[Category: Hydroxysteroid]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | ||
| + | [[Category: Sdr]] | ||
Revision as of 08:24, 2 November 2011
Crystal structure of 11b-hsd1 double mutant (l262r, f278e) complexed with 8-{[(2-CYANOPYRIDIN-3-YL)METHYL]SULFANYL}-6-HYDROXY-3,4-DIHYDRO-1H-PYRANO[3,4-C]PYRIDINE-5-CARBONITRILE
Template:ABSTRACT PUBMED 21983444
About this Structure
3tfq is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Wu SC, Yoon D, Chin J, van Kirk K, Seethala R, Golla R, He B, Harrity T, Kunselman LK, Morgan NN, Ponticiello RP, Taylor JR, Zebo R, Harper TW, Li W, Wang M, Zhang L, Sleczka BG, Nayeem A, Sheriff S, Camac DM, Morin PE, Everlof JG, Li YX, Ferraro CA, Kieltyka K, Shou W, Vath MB, Zvyaga TA, Gordon DA, Robl JA. Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11beta-hydroxydehydrogenase 1 (11beta-HSD1). Bioorg Med Chem Lett. 2011 Nov 15;21(22):6693-8. Epub 2011 Sep 21. PMID:21983444 doi:10.1016/j.bmcl.2011.09.058
